Results 91 to 100 of about 8,773,435 (248)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Refined edge detection model based on RCF

Journal of Measurement Science and Instrumentation
Edge detection is a fundamental method in image processing and computer vision. Aiming to address the issues of roughness and blurriness in edges generated by deep learning-based edge detection technology, a refined edge detection(RED) model based on ...
ZHAO Weidong, ZHANG Yao, ZHANG Dandan, LING Qiang   +3 more
doaj  

Asteroseismology of 16,000 Kepler Red Giants: Global Oscillation Parameters, Masses, and Radii

, 2018
The Kepler mission has provided exquisite data to perform an ensemble asteroseismic analysis on evolved stars. In this work we systematically characterize solar-like oscillations and granulation for 16,094 oscillating red giants, using end-of-mission ...
Timothy R. Bedding, Khanna, Shourya, Stello, Dennis, Simon J. Murphy, Shourya Khanna, Jie Yu, Dennis Stello, Hon, Marc, Huber, Daniel, Marc Hon, Murphy, Simon J., Bedding, Timothy R., Daniel Huber, Yu, Jie   +13 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Dual energy-differentiated topological transition in artificial red phosphorus chains

Physical Review Research
We investigate the spectral and topological properties of an atomic chain of red phosphorus. We reveal the separation of flat-band states from the rest of the system and calculate its energy bands analytically.
Vít Jakubský, B. Manjarrez-Montañez, Rafael A. Méndez-Sánchez, Yonatan Betancur-Ocampo   +3 more
doaj   +1 more source

Multiscale feature enhancement and lightweight ensemble modeling for hyperspectral chlorophyll inversion in greenhouse tomato

Smart Agricultural Technology
Chlorophyll content measured by a Soil and Plant Analyzer Development (SPAD) meter is a key indicator of nitrogen status and photosynthetic capacity in greenhouse-grown tomatoes.
Lingang Xiao, Yan Ma, Xingdong Gao, Bingwei Song, Letian Wu   +4 more
doaj   +1 more source