Results 61 to 70 of about 8,773,435 (248)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Red Jordan Press Catalogue (2005)

, 2005
A self-published catalogue that lists available books, poems, and plays. The catalogue also includes descriptions of the publications, and information about how to order with prices. Towards the end of the booklet there is an updated biography and a list
Arobateau, Red Jordan
core   +1 more source

ESTIMATION OF SUGARCANE YIELD USING MULTI-TEMPORAL SENTINEL 2 SATELLITE IMAGERY AND RANDOM FOREST REGRESSION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Advancements in remote sensing techniques have greatly enhanced crop monitoring and yield estimation, with spectral vegetation indices (VIs) serving as a key component. Our study investigates the use of Sentinel-2 data, notable for its red-edge bands, in
A. Taravat, G. Abebe, G. Abebe, B. Gessesse, T. Tadesse   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Early detection of orange spotting disease in oil palm using red edge parameters [PDF]

, 2018
Viroids are single-stranded, low molecular weight, circular RNA between 246 and 401 nucleotides that lacks a protective protein coat. Viroids have only been found in the plants. Coconut cadang-cadang viroid (CCCVd; Genus Cocadviroid, Family Pospiviroidae)
Golhani, Kamlesh
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Imaging spectroscopy for bark beetle detection in Norway spruce and the relevance of the red-edge spectral range

International Journal of Applied Earth Observations and Geoinformation
In this study, hyperspectral data of two geographically distant study areas in Germany were analyzed to find the most effective spectral wavelengths for red-edge-based vegetation indices to differentiate bark beetle-infested Norway spruce into three ...
Alexander Marx, Anne Clasen, Johannes May, Simon König, Birgit Kleinschmit, Michael Förster   +5 more
doaj   +1 more source

Unsupervised Monitoring Vegetation after the Closure of an Ore Processing Site with Multi-Temporal Optical Remote Sensing

Sensors, 2020
Ore processing is a source of soil heavy metal pollution. Vegetation traits (structural characteristics such as spatial cover and repartition; biochemical parameters—pigment and water contents, growth rate, phenological cycle…) and plant species identity
Sophie Fabre, Rollin Gimenez, Arnaud Elger, Thomas Rivière   +3 more
doaj   +1 more source

acb08/relative-edge-response: Relative Edge Response for Gaussian Point Spread Functions

, 2022
Analysis code to study the relationship between Gaussian blur parameters and relative edge response using synthetic edge image ...
acb08
core   +1 more source