Results 31 to 40 of about 561,590 (256)
Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceGreen plants in the red : a baseline global assessment for the IUCN Sampled Red List Index for Plants
, 2015 Plants provide fundamental support systems for life on Earth and are the basis for all terrestrial ecosystems; a decline in plant diversity will be detrimental to all other groups of organisms including humans. Decline in plant diversity has been hard to Vanessa Coldwell, Sarah Tingvoll, Linda Murray (781097), Ruth Harker (636247), Mireya Quiton Tuijtelaars (781100), Patricia Malcolm-Tompkins, Cockel, Chris, Lindon, Heather, Linda Murray, James Lyon (781094), Vanessa Coldwell (781077), Keara Nazar, Atchison, Guy, Lyon, James, Brummitt, Neil, Celesti, Marco, Gardiner, Lauren, Lopez-Poveda, Lucia, Aljos Farjon, Barlozzini, Barbara, Concetti, Benedetta, Ruth Harker, Coldwell, Vanessa, Thomas R. Meagher (420346), Sarah Tingvoll (781105), Meagher, Thomas Robert, John S. Donaldson (781064), Sara Contu, Debora Lombrici (781092), Kirsty McGregor (781096), Alice Groom, Albuquerque, Sara, Baloch, Elisabeth, Crook, Vicki, Emily Power, Chris Cockel (781076), Philippa Dyson, Alice Groom (781085), Thomas, Leighton J., Power, Emily, Sonia Khela (781087), Farjon, Aljos, Lockwood, Helen, Della Hopkins, Gemma Watkinson, Maiko Lutz (781061), Elina Aletrari, Heather Lindon, Vicki Crook, Aljos Farjon (781063), Eduardo Cianfoni, Hannah Greene, Watkinson, Gemma, Malcolm-Tompkins, Patricia, Greene, Hannah, McGregor, Kirsty, Leighton J. Thomas (781104), Ghanim, Nadia, Marco Celesti, Nazar, Keara, A. Kei Andrews (781067), Quiton Tuijtelaars, Mireya, Donaldson, John, Emily Power (781099), Lakeman-Fraser, Poppy, Nic Lughadha, Eimear, Hilton-Taylor, Craig, Carretero, Julia, Philippa Dyson (781081), Alice Brunazzi (781071), Robert Segrott, Khela, Sonia, Nadia Ghanim (781083), Mireya Quiton Tuijtelaars, Laura Moreno (145381), Barbara Barlozzini (781070), Sara Albuquerque, Leighton J Thomas, Steven P Bachman, Helen Lockwood (781090), Lauren Gardiner (781082), Salter, Ruth, Murray, Linda, Katerina Wojtaszekova (781107), Helen Chadburn, Wojtaszekova, Katerina, Hannah Thacker (781103), Nadia Ghanim, Julia Carretero, Brummitt, Neil A., Keara Nazar (781098), Neil A Brummitt, Thacker, Hannah, Lombrici, Debora, Sonia Khela, Christine Loftus, Ruth Salter, Benedetta Concetti, Ciafoni, Eduardo, Alice Brunazzi, Cianfoni, Eduardo, John S Donaldson, Robert Segrott (781102), Dyson, Philippa, Hannah Greene (781084), Justin F. Moat (781062), Hopkins, Della, Steven P. Bachman (606356), Hannah Thacker, Poppy Lakeman-Fraser, Elisabeth Baloch (781069), Julia Carretero (781072), Poppy Lakeman-Fraser (781088), Marco Celesti (781073), Laura Moreno, Maiko Lutz, Brunazzi, Alice, Janine Griffiths-Lee, A Kei Andrews, Guy Atchison, Sara Albuquerque (781065), Debora Lombrici, Harker, Ruth, Heather Lindon (781089), Aletrari, Elina, Lutz, Maiko, James Lyon, Moat, Justin, Thomas R Meagher, Kirsty McGregor, Lauren Gardiner, Patricia Malcolm-Tompkins (781095), Moreno, Laura, Helen Lockwood, Eduardo Cianfoni (781075), Neil A. Brummitt (781059), Elina Aletrari (781066), Helen Chadburn (781074), Sara Contu (781079), Segrott, Robert, Justin F Moat, Janine Griffiths-Lee (781060), Griffiths-Lee, Janine, Nic Lughadha, Eimear M., Bachman, Steven, Tingvoll, Sarah, Craig Hilton-Taylor, Barbara Barlozzini, Chris Cockel, Vicki Crook (781080), Loftus, Christine, Ruth Salter (781101), Donaldson, John S., Lucia Lopez-Poveda (781093), Meagher, Thomas R., Lucia Lopez-Poveda, Eimear M Nic Lughadha, Guy Atchison (781068), Contu, Sara, Katerina Wojtaszekova, Gemma Watkinson (781106), Bachman, Steven P., Andrews, A. Kei, Chadburn, Helen, Benedetta Concetti (781078), Loftu, Christine, Elisabeth Baloch, Eimear M. Nic Lughadha (781108), Christine Loftus (781091), Craig Hilton-Taylor (57131), Groom, Alice, Della Hopkins (781086) +171 morecore +1 more sourceAlien plants in urban nature reserves : from red-list species to future invaders?
, 2011 Urban reserves, like other protected areas, aim to preserve species richness but conservation efforts in these protected areas are complicated by high proportions of alien species.Vojtěch Jarošik, Kadlec, Tom\ue1š, Petr Pyšek, Jarošík, Vojtěch, Kadlec,Tomáš, Pyšek,Petr, Kadlec, Tomáš, Tomáš Kadlec, Jarošik,Vojtěch, Pyšek, Petr +9 morecore +1 more sourceMycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci +7 morewiley +1 more sourceIncreasing loss of mature boreal forests around protected areas with red-listed forest species
, 2022 Background
Protected areas (PA) are central to biodiversity, but their efficiency is challenged by human-induced habitat loss and fragmentation. In the Fennoscandian boreal region, forestry with clearcutting is a threat to biodiversity causing the loss ...Virkkala, Raimo, Määttänen, Aino-Maija, Heikkinen, Risto K., Leikola, Niko +3 morecore +1 more sourceScreening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu +9 morewiley +1 more sourceDo species conservation assessments capture genetic diversity?
, 2014 This work was supported by the Natural Environment Research Council NER/S/A/2006/14303 (MR) and the Leverhulme Trust RF/2/RFG/2007/0314 (TM).The best known system for classifying threat status of species, the IUCN Red List, currently lacks explicit ...Neil A. Brummitt, Brummitt, N. A., Malin C. Rivers, Meagher, Thomas R., Rivers, Malin C., Rivers, Malin Cecilia, Meagher, T. R., Nic Lughadha, E. M., Brummitt, Neil, Rivers, M. C., Eimear Nic Lughadha, Meagher, Thomas Robert, Brummitt, Neil A., Thomas R. Meagher, Nic Lughadha, Eimear +14 morecore +1 more source
