Results 61 to 70 of about 8,246,076 (287)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Transferability of 34 red-listed peatland plant species models across boreal vegetation zone

Ecological Indicators, 2021
Red-listed species are negatively affected by habitat degradation and fragmentation. They usually have small populations and may be affected by local extinctions which makes species distribution modeling (SDM) challenging.
Parvez Rana, Anne Tolvanen
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

New records and an updated list of reptiles from Thanh Hoa Province, Vietnam [PDF]

Biodiversity Data Journal
Thanh Hoa Province is located in North Central Vietnam and the Province contains a large area of 393,361.33 hectares of natural forest. A complexity of landforms has given this Province a high level of biodiversity potential.
Vinh Dau, Thao Hoang, Truong Nguyen, Anh Pham   +3 more
doaj   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Factors structuring estuarine and coastal fish communities across Japan using environmental DNA metabarcoding

Ecological Indicators, 2021
Estuarine and coastal ecosystems are important habitats for many fish species. Large-scale patterns of estuarine and coastal fish communities can be affected by geographical factors, such as water temperature and latitude, that limit or allow fish ...
Manabu Kume, Edouard Lavergne, Hyojin Ahn, Yuki Terashima, Kohmei Kadowaki, Feng Ye, Satoshi Kameyama, Yoshiaki Kai, Yumi Henmi, Yoh Yamashita, Akihide Kasai   +10 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

NEW RECORDS AND UPDATE LIST SPECIES OF TURTLES IN PU LUONG NATURE RESERVE, THANH HOA PROVINCE

Tạp chí Khoa học
The paper provides morphological data of three turtle species: Black-breasted Leaf Turtle Geoemyda spengleri (Gmélin, 1789), Impressed Turtle Manouria impressa (Günther, 1882), and Big-headed Turtle Platysternon megacephalum Gray, 1831, which were ...
Dau Quang Vinh*, Do Thi Ly, Ha Thi Thao, Le Thi Quynh, Ha Thi Thao, Le Thi Thu Phuong, Le Dinh Phuong   +1 more
doaj   +1 more source