Results 251 to 260 of about 21,414,113 (306)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

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Relative energy deficiency in sport (RED-S)

British Journal of Sports Medicine, 2017
Relative energy deficiency in sport (RED-S) is the result of insufficient caloric intake and/or excessive energy expenditure. Consequences of this low-energy condition can alter many physiological systems, including metabolism, menstrual function, bone health, immunity, protein synthesis, and cardiovascular and psychological health1 (figure 1 ...
Siobhan M, Statuta, Irfan M, Asif, Jonathan A, Drezner   +2 more
openaire   +2 more sources

Relatives Energiedefizit im Sport (RED-S)

Gynäkologische Endokrinologie, 2021
Immer wieder finden sich Sportler mit vielfaltigen Erkrankungen und Untergewicht. Es kann ein relatives Energiedefizit im Sport (RED-S) zugrunde liegen. Dies gilt es, fruhzeitig zu erkennen und im Team zu behandeln. In ein solches Team gehoren dann der behandelnde Arzt, Ernahrungsberater, Psychologen, Gynakologen, Endokrinologen und naturlich der ...
openaire   +1 more source

The In Vivo Inhibition of Bone Formation by Alizarin Red S

The Journal of Bone & Joint Surgery, 1964
Significant inhibition of bone formation in dogs was observed in areas of intense skeletal uptake of alizarin red S. Electron microscopy revealed that the organic matrix in these areas was severely disturbed. The areas which contained no recognizable collagen had the least mineral.
W H, HARRIS, D F, TRAVIS, U, FRIBERG, E, RADIN   +3 more
openaire   +2 more sources

Microdetermination of alizarine red S

Microchemical Journal, 1968
Abstract Alizarin red S is determined by oxidation with ceric sulfate. Oxidation results in the formation of phthalic acid and formic acid at 14 equivalence. Maximum error observed was + 2.7%.
openaire   +1 more source

Alizarin Red S As An Intravital Fluorochrome in Mineralizing Tissues

Stain Technology, 1965
To avoid interference with weight gain following alizarin red S injections, low doses of an order of 25 mg/kg body weight must be used. Two such doses given 4 days apart to 24-day-old rats produced no visible staining of bone or dentine in undecalcified sections examined by ordinary light microscopy.
openaire   +4 more sources