Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy
Annals of Neurology, EarlyView.Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos +46 more
wiley +1 more source
Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy
Angewandte Chemie, EarlyView.Inspired by mechanoenzymes, a ferrocene‐based mechanically regulated nanozyme converts acoustic shear force into enhanced peroxidase‐like activity by decreasing electron density and alleviating steric hindrance at the Fe active sites, thereby rewiring redox homeostasis. Leveraging this remote regulatory mechanism, a multienzyme‐regulated nanoreactor is
Fangman Chen +13 more
wiley +2 more sources
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro +3 more
wiley +1 more source
Molecular profiles of red blood cells across geographic, pathological, and age-related perspectives: translational insights. [PDF]
Front Med (Lausanne)Almadhaani KY, Altaie AM, Hamoudi R.
europepmc +1 more source
Recover aged/damaged erythrocytes and prevent them from aging by remodeling or enhancing their vital proteins: Hb and B3p. [PDF]
Front Cell Dev BiolJiang GY +4 more
europepmc +1 more source
Personalized Exercise Training Modulates Red Blood Cell Rheology and Morphology in Long COVID. [PDF]
Int J Mol SciKrüger AL +4 more
europepmc +1 more source
Rheological and biochemical comparison of cord and adult blood red cells for transfusion applications. [PDF]
Sci RepMykhailova L +10 more
europepmc +1 more source
Determinants of red blood cell deformability in relation to cell age
European Journal of Haematology, 1994 Abstract: Red blood cell (RBC) deformability was determined with an ektacytometer in fractions separated on the basis of differences in cell volume or density. Deformability was measured with ektacytometry (rpm‐scan and osmo‐scan). We studied three groups of RBC fractions: 1.
F H Bosch
exaly +7 more sources
Red blood cell deformability in multiple myeloma1
Clinical Hemorheology and Microcirculation, 2018 The aim of this study was the evaluation of the erythrocyte deformability in multiple myeloma (MM). We enrolled 29 MM patients and we evaluated, on fasting venous blood, the erythrocyte deformability, expressed as elongation index, and examined using the diffractometric method.
Gregorio, Caimi +6 more
openaire +3 more sources