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Red blood cell deformability and protein adsorption on red blood cell surface
American Journal of Physiology-Heart and Circulatory Physiology, 1984 Effects of protein and NaCl concentrations in plasma on red blood cell (RBC) deformability were studied using fresh human blood and a 5-microns Nuclepore filtration test. The protein and salt concentrations were varied by diluting the plasma with saline and adding crystalline NaCl to the fluids, respectively.
Y, Kikuchi, T, Koyama
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Analyzing Red Blood Cell-Deformability Distributions
Blood Cells, Molecules, and Diseases, 2002Red blood cells (RBCs) must deform to pass the smallest capillaries of the microcirculation. Available techniques for measuring RBC deformability often provide an indication of the mean deformability. The latter may be decreased either by a slight overall deformability reduction or by the presence of a small fraction of rigid cells.
Johannes G G Dobbe +2 more
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Microfluidic analysis of red blood cell deformability
Journal of Biomechanics, 2014A common indicator of rheological dysfunction is a measurable decrease in the deformability of red blood cells (RBCs). Decreased RBC deformability is associated with cellular stress or pathology and can impede the transit of these cells through the microvasculature, where RBCs play a central role in the oxygenation of tissues.
Simon P Duffy +2 more
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Dipyridamole increases human red blood cell deformability
European Journal of Clinical Pharmacology, 1992 An automated filtration technique has been used to investigate the effect of dipyridamole (DP) on red blood cell deformability in patients identified as having rigid red cells. They were patients on haemodialysis (HD) for chronic renal failure (n = 18), patients with peripheral vascular disease (PVD, n = 23) and controls (hospital outpatients, n = 33).
Saniabadi, AR +6 more
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Association of reduced red blood cell deformability and diabetic nephropathy
Kidney International, 2005 Association of reduced red blood cell deformability and diabetic nephropathy.BackgroundImpaired red blood cell deformability may play a key role in the pathogenesis of chronic vascular complications of diabetes mellitus and progression of renal failure ...
Clinton D Brown, Eli A Friedman
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Technologies for measuring red blood cell deformability
Lab on a Chip, 2022Advances in microfluidic technologies for measuring red blood cell deformability have surpassed traditional methods in terms of sensitivity, throughput, and ease of use. This review describes, compares, and covers applications of these technologies.
Kerryn Matthews +4 more
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Deformation of Red Blood Cells in Capillaries
Science, 1969The shapes of red blood cells in capillary blood vessels are reinterpreted from observations of human red cells. The parachute or umbrella shape often observed is not an axisymmetric shape as formerly assumed, but is the basic biconcave disk shape of the red cell with the upstream end flattened by the pressure gradient.
R, Skalak, P I, Branemark
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Red Blood Cell Deformability in Sepsis
American Journal of Respiratory and Critical Care Medicine, 1998Abstract The microcirculatory disturbances in sepsis have prompted micropore bulk-filtration studies of red blood cell (RBC) mechanical behavior (i.e., deformability). However, these prior reports may not solely reflect RBC behavior because of possible white blood cell (WBC) occlusion of the filter pores.
O K, Baskurt, D, Gelmont, H J, Meiselman
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Red blood cell deformability and the prostaglandins
Prostaglandins, 1973Abstract The effects of Prostaglandin E 1 and Prostaglandin E 2 on the deformability of the human red blood cell have been studied using the glass micropipette method. In the range of concentrations 10 −13 to 10 −5 M, neither PGE 1 nor PGE 2 alters the red cell deformability.
A W, Jay, S, Rowlands, L, Skibo
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Elastic deformations of red blood cells
Journal of Biomechanics, 1977Abstract Large, elastic deformations of red blood cells are computed on the basis of an assumed model of the red blood cell membrane which includes the elasticity of the membrane under tensions in its own plane and the bending elasticity. The analysis is based on a variational principle implemented by a finite element method.
P R, Zarda, S, Chien, R, Skalak
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