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Red Blood Cell Deformability in Human and Experimental Sepsis
Archives of Surgery, 1988Red blood cell (RBC) "deformability" is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 +/- 0.12) compared with patients ...
T C, Hurd +3 more
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Continuum modeling of deformation and aggregation of red blood cells
Journal of Biomechanics, 2016In order to gain better understanding for rheology of an isolated red blood cell (RBC) and a group of multiple RBCs, new continuum models for describing mechanical properties of cellular structures of an RBC and inter-cellular interactions among multiple RBCs are developed.
Daegeun Yoon, Donghyun You
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Red Cell Deformability And Its Relevance To Blood Flow
Annual Review of Physiology, 1987The resistance to blood flow is a function of the rheological properties of blood as well as the geometric features of blood vessels. While circulatory investigations generally aim at studying the functions of the heart and blood vessels, there is an increasing realization that blood rheology can also play a significant role in circulatory regulation ...
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Eadie-Hofstee analysis of red blood cell deformability
Clinical Hemorheology and Microcirculation, 2011In recent years, linear data transformation has become an accepted method to simplify the analysis of red blood cell (RBC) deformability curves obtained by ektacytometry. In this study, we introduce the Eadie-Hofstee transformation as an alternative linearization method for the analysis of RBC deformability.
H, Stadnick +3 more
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Lack of Effect of Pentoxifylline on Red Blood Cell Deformability
The Journal of Clinical Pharmacology, 1992The proposed mechanism of action for pentoxifylline's beneficial effect in peripheral vascular disease is an improvement in red blood cell deformability. Likewise, single doses of pentoxifylline in healthy volunteers have been shown to improve whole blood filterability, which was suggested to occur as a result of augmented red blood cell deformability.
D M, Cummings, S K, Ballas, M J, Ellison
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Photodynamic effects of protoporphyrin on red blood cell deformability
Biochemical and Biophysical Research Communications, 1977Summary Human erythrocytes exposed to visible light in the presence of protoporphyrin showed a pronounced decrease of cell deformability. The photodynamic action of protoporphyrin on red blood cells has previously been shown to cause a.o. an extensive cross-linking of spectrin. As spectrin is presumably involved in processes regulating cell shape and
T M, Dubbelman +2 more
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Effect of carbonyl compounds on red blood cells deformability
Biochemical and Biophysical Research Communications, 2004The effect of Maillard reaction on red blood cells (RBC) deformability was investigated. Exposure of RBC to carbonyl compounds (dl-glyceraldehyde, glyoxal, glycolaldehyde, 3-deoxyglucosone, and d-glucose) leading to Maillard reaction caused a marked decrease in RBC deformability even at 1mM level.
Hiroyoshi, Iwata +4 more
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Effects of nitric oxide on red blood cell deformability
American Journal of Physiology-Heart and Circulatory Physiology, 2003In addition to its known action on vascular smooth muscle, nitric oxide (NO) has been suggested to have cardiovascular effects via regulation of red blood cell (RBC) deformability. The present study was designed to further explore this possibility. Human RBCs in autologous plasma were incubated for 1 h with NO synthase (NOS) inhibitors [ Nω-nitro-l ...
Melek, Bor-Kucukatay +3 more
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Deformation of red blood cells and the viscoelastic properties of a concentrated red cell suspension
Biorheology, 1984The viscoelastic properties of a concentrated red cell suspension in which red cells do not form rouleaux are discussed from a theoretical point of view. An elastic spherical shell filled with a viscous fluid is considered as a model of a normal red cell. A cell method is used to consider finite concentration of suspended particles.
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Red blood cell motion and deformation in a curved microvessel
Journal of Biomechanics, 2017The flow of cells through curved vessels is often encountered in various biomedical and bioengineering applications, such as red blood cells (RBCs) passing through the curved arteries in circulation, and cells sorting through a shear-induced migration in a curved channels. Most of past numerical studies focused on the cell deformation in small straight
Ting, Ye +3 more
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