Results 51 to 60 of about 13,736,860 (303)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Red blood cell distribution width predicts results of dipyridamole stress testing.

, 2014
Red blood cell distribution width predicts results of dipyridamole stress ...
Cervellin G., Ruffini L, LIPPI, Giuseppe
core   +1 more source

Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction [PDF]

, 2011
Objectives Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI)
Onturk, Ebru Tekbas, Gibson, C. Michael, Erer, Hatice Betul, Huseyin Uyarel, Hatice Betul Erer, Ersin Yildirim, Mehmet Gungor Kaya, Yesilcimen, Kemal, Kaya, Mehmet Güngör, Turkkan, Ceyhan, Yildirim, Ersin, Erkan Ayhan, Mehmet Ergelen, Veli Kirbas, Uyarel, Huseyin, Ceyhan Turkkan, Cicek, Gokhan, Ergelen, Mehmet, Ebru Tekbas Onturk, Gokhan Cicek, Ayhan, Erkan, Kemal Yesilcimen, Kirbas, Veli, C. Michael Gibson, Yıldırım, Ersin, Kırbaş, Veli   +25 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Investigating the role of red cell and platelet distribution width-to-platelet ratios in diagnosing early-onset neonatal sepsis

Iraqi Journal of Hematology
BACKGROUND: Early and accurate diagnosis of early-onset neonatal sepsis (EONS) is vital in improving survival and outcome in affected neonates. To date, no single inflammatory biomarker has demonstrated both high sensitivity and specificity for the ...
Nabeeha Najatee Akram, Shahad Ali Ahmed Al-Baldawi, Essam Ahmed Abdullah, Shaymaa Khalid Abdulqader   +3 more
doaj   +1 more source

DIAGNOSTIC EFFICACY OF RED BLOOD CELL INDICES IN DIAGNOSIS OF BETA THALASSEMIA TRAIT TAKING HAEMOGLOBIN ELECTROPHORESIS AS GOLD STANDARD

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the diagnostic efficacy of haematological indices for the diagnosis of beta thalassemia trait taking haemoglobin electrophoresis as a gold standard. Study Design: Cross sectional study.
Sahar Rabbani, Muhammad Farooq, Samina Naeem, Nasir Uddin, Muhammad Abdul Naeem, Shahneela Jabeen   +5 more
doaj   +1 more source

Clinical characteristics of participants according to the red blood cell distribution width.

, 2016
Clinical characteristics of participants according to the red blood cell distribution width.
Hyun-Sook Kim (2502988), Han-Bin Lee (828365), Seung-Hun Oh (128390), Soonhag Kim (602122), Won-Chan Kim (128400), Jinkwon Kim (828366), Sang-Heum Kim (828367), Ok-Joon Kim (128403)   +7 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Red blood cell distribution width-to-albumin ratio and osteoarthritis: A cross-sectional and cohort study

Journal of International Medical Research
Background The red cell distribution width-to-albumin ratio is a novel composite biomarker reflecting systemic inflammation and nutritional status. This study aimed to evaluate the association between the red cell distribution width-to-albumin ratio and ...
Jiaming Tang, Jing Li, Rulai Yang
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source