Results 1 to 10 of about 11,468 (139)
Brain Organoids to Evaluate Cellular Therapies
Animals, 2022 Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, especially in the brain. Therefore,
Ana Belén García-Delgado +8 more
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Stem Cell Research & Therapy, 2023 Background There remains much interest in improving cryopreservation techniques for advanced therapy medicinal products (ATMPs). Recently, human platelet lysate (hPL) has emerged as a promising candidate to replace fetal bovine serum (FBS) as a xeno-free
María Martín-López +8 more
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Stem Cells Translational Medicine, 2020 Intraventricular hemorrhage is a common cause of morbidity and mortality in premature infants. The rupture of the germinal zone into the ventricles entails loss of neural stem cells and disturbs the normal cytoarchitecture of the region, compromising ...
Beatriz Fernández‐Muñoz +14 more
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A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis
Cells, 2020 NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS).
Sonsoles Barriola +4 more
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Frontiers in Neuroscience, 2021 Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best ...
Raquel Sanchez-Varo +34 more
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Cell Transplantation, 2010 To address a number of questions regarding the experimental use of bone marrow (BM) stem cells in hindlimb ischemia, including which is the best cell type (e.g., purified hematopoietic stem cell or monocytes), the best route of delivery [intramuscular ...
Fermin M. Sanchez-Guijo M.D., PhD. +11 more
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Cell Transplantation, 2013 Hematopoietic stem cell transplantation (HSCT) using umbilical cord blood (UCB) progenitors is increasingly being used. One of the problems that may arise after UCB transplantation is an impaired engraftment.
S. Carrancio +10 more
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Assessment of Olfactory Behavior in Mice: Odorant Detection and Habituation-Dishabituation Tests
Bio-Protocol, 2015 Olfaction has adaptive value for rodents as it is essential for feeding and mating, the establishment of social and territorial relationships, or the detection of potential predators, among others (Apfelbach et al., 2005).
Ana Perez-Villalba +3 more
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Mercury intoxication and ophthalmic involvement: An update review
Frontiers in Toxicology, 2023 Human intoxication after mercury exposure is a rare condition that can cause severe damage to the central nervous, respiratory, cardiovascular, renal, gastrointestinal, skin, and visual systems and represents a major public health concern.
Cristian de los Santos +5 more
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Generation of an induced pluripotent stem cell line from a compound heterozygous patient in TK2 gene
Stem Cell Research, 2022 Autosomal recessive mutations in Thymidine kinase 2 (TK2) gene cause depletion and multiple deletions in mtDNA which normally lead to fatal and progressive neuromyopathy in infants and children.
Carmen Hernández-Ainsa +6 more
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