Results 101 to 110 of about 3,023,691 (351)

Seeing Red: Inside the Science and Politics of the IUCN Red List

open access: yesConservation & Society, 2012
The Red List of Threatened Species™ (hereafter Red List) is the International Union for the Conservation of Nature′s most recognisable product. The Red List categorises the conservation status of species on a global scale using ′the most objective ...
Lisa M Campbell
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The Steppe Eagle Global Conservation Status Was Raised

open access: yesПернатые хищники и их охрана, 2015
An announcement which gives the current status of the steppe eagle in European Red List and IUCN Red List and reviews its status change in Russia and Kazakhstan.
Igor V. Karyakin
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

European Red List of Trees [PDF]

open access: yes, 2019
The European Red List is a review of the status of European species according to IUCN regional Red Listing guidelines. It identifies those species that are threatened with extinction at the regional level – in order that appropriate conservation action can be taken to improve their status.
Rivers M. C.   +35 more
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

THE QUESTION OF THE CONSERVATION OF WILD RELATIVES OF CULTIVATED PLANTS IN THE TERRITORY OF LENINGRAD, NOVGOROD AND PSKOV REGIONS

open access: yesТруды по прикладной ботанике, генетике и селекции, 2018
Improved method for the selection of taxa for the regional red list, developed scoring system for inclusion of taxa on the red list CWR and preserve them in situ in the respective regions.
L. J. Shipilina
doaj   +1 more source

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