Results 121 to 130 of about 3,739,606 (279)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Lithocarpus braianensis. The IUCN Red List of Threatened Species 2023

, 2023
IUCN ...
Ngoc, Nguyen Van
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Global extinction risk assessment of soil-dependent species: recent progress and recommendations

Oryx
Soil biodiversity is crucial to the maintenance of multiple critical ecosystem functions and services. However, remarkably little is known about the conservation status of most soil-dependent species.
Neil Ashley Cox, James Westrip, Philip Bowles, Craig Hilton-Taylor, Axel Hochkirch, Richard K. B. Jenkins, Gregory M. Mueller, Paulo A. V. Borges, Maria J. I. Briones, Cátia Canteiro, V. Bala Chaudhary, Monica A. Farfan, Rodrigo Feitosa, Carlos A. Guerra, Konstantin B. Gongalsky, Sergio Henriques, John S. LaPolla, Camila Leandro, Zoë Lindo, Bethan Manley, Catherine Numa, Sebahat K. Ozman-Sullivan, J. Jacob Parnell, Anton Potapov, Alberto Martín Sánchez, Marla Schwarzfeld, Patricia A. Silva-Flores, Gregory T. Sullivan, Maria Tsiafouli, Fernando Z. Vaz-de-Mello, Leena Vilonen, Andrey Zaitsev   +31 more
doaj   +1 more source

THE QUESTION OF THE CONSERVATION OF WILD RELATIVES OF CULTIVATED PLANTS IN THE TERRITORY OF LENINGRAD, NOVGOROD AND PSKOV REGIONS

Труды по прикладной ботанике, генетике и селекции, 2018
Improved method for the selection of taxa for the regional red list, developed scoring system for inclusion of taxa on the red list CWR and preserve them in situ in the respective regions.
L. J. Shipilina
doaj   +1 more source

Lithocarpus coinhensis. The IUCN Red List of Threatened Species 2023

, 2023
IUCN ...
Ngoc, Nguyen Van
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

List of Sites of Red Memory

, 2019
The following list is based on the first list of 100 red tourism scenic spots was published in the People’s Daily (Renmin Ribao) on the 24th and 25th March 2005 (全国红色旅游经典景区) (List here: Link 1, Link 2, Link 3).
redmemory
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source