Results 41 to 50 of about 664,667 (305)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Chimera states in a multilayer network of coupled and uncoupled neurons

, 2017
We study the emergence of chimera states in a multilayer neuronal network, where one layer is composed of coupled and the other layer of uncoupled neurons.
Ghosh, Dibakar, Majhi, Soumen, Perc, Matjaz   +2 more
core   +1 more source

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. [PDF]

, 2016
BackgroundHIV-associated neurocognitive disorders (HAND) continue to be a common morbidity associated with chronic HIV infection. It has been shown that HIV proteins (e.g., gp120) released from infected microglial/macrophage cells can cause neuronal ...
Achim, Cristian, Adame, Anthony, Desplats, Paula, Fields, Jerel A, Florio, Jazmin, Mante, Michael, Masliah, Eliezer, Overk, Cassia, Pineda, Andrea, Rockenstein, Edward   +9 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Modelo De Memoria Usando Red Neuronal De Retropropagación

Revista Tecnológica, 2012
El trabajo presentado muestra el uso de la Red Neuronal de Retropropagación para el reconocimiento de patrones en tres dimensiones; a través de una simulación computarizada se consiguió reproducir el mecanismo de reconocimiento de objetos.
Ramiro Alejandro Yerovi Vargas
doaj   +4 more sources

Predicción de parámetros de una planta de craqueo catalítico de fluidos - FCC mediante modelos neuronales

Revista UIS Ingenierías, 2002
A partir del conocimiento de una unidad de craqueo catalítico de fluidos - FCC de unarefinería europea se presenta el diseño de modelos neuronales capaces de predecir ciertosparámetros de la planta, restringidos a la zona de operación de la cual se posee
Oscar M. Reyes T., Diana K: Hurtado F., Oscar Gualdrón G.   +2 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

La IA Generativa en el Desarrollo de Software: Impacto en Diversas Industrias

Innovación y Software
El desarrollo de software experimentó una transformación significativa mediante la integración de tecnologías de inteligencia artificial (IA) generativa.
Guliana Lulichac Ramos, Fernando Olivert Pantoja Payajo, Marcelino Torres Villanueva   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Diseño y Análisis de desempeño de un inversor de voltaje utilizando controladores inteligentes

Maskay, 2013
El presente documento describe el desarrollo de controladores inteligentes, para la supresión de armónicos en inversores monofásicos con modulación senoidal por ancho de pulso (SPWM).
Juan jose Salazar
doaj   +1 more source