Results 121 to 130 of about 5,284,284 (237)

Thermal responses and Symbiodiniaceae shuffling in a Red Sea foraminifer holobiont. [PDF]

ISME Commun
Pinko D, Kenigsberg C, Levin S, Langlet D, Husnik F, Holzmann M, Abdu U, Abramovich S.   +7 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Spatial distribution of selected coastal Sabkhas along the Southern Red Sea Coast of Egypt. [PDF]

Sci Rep
Younis NA, El-Habaak GH, El Hadek HH, Galal WF, Abdel-Hakeem M.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Seasonal dynamics of trace elements, sediment contamination, and child health risks in six Egyptian red sea ports: an integrated water-sediment-human health assessment. [PDF]

Environ Geochem Health
Abdallah IM, Mohamedein LI, El-Moselhy KM, El-Sawy MA.   +3 more
europepmc   +1 more source

Sea Straits and Glacial Periods in the Red Sea [PDF]

Science, 1977
openaire   +4 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Tissue-specific distribution of cytotoxic triterpene saponins in three Red Sea sea cucumbers. [PDF]

Sci Rep
Fayez S, Abed K, Moussa MS, Zohdy MN, Ali AM, El-Gohary MA, Awaad MM, Alshawarby NM, Sedky RI, Taha ME, El-Sayed TH, Abd Elhamied EM, Mahmoud NG, Serafeem TE, Chen PJ, Huang HC, Chen LY, Lai KH, El-Shazly M.   +18 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

A new cave-dwelling species of <i>Trimma</i> (Teleostei, Gobiidae) from the Red Sea, with notes on Red Sea endemism in <i>Trimma</i> spp. [PDF]

Zookeys
Peinemann VN, Pombo-Ayora L, Rich WA, Fox MD, Coker DJ.   +4 more
europepmc   +1 more source