Results 131 to 140 of about 257,904 (307)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Infection and Drug ResistanceSamuel Tekle Mengistu,1 Yafet Kesete,2 Meron Tesfay,2 Ghirmay Ghebrekidan Ghebremeskel,1 Saron Abraham,2 Mohammed Elfatih Hamida,3 Oliver Okoth Achila4 1Clinical Medicine, Nakfa Hospital, Nakfa, Eritrea; 2Clinical Laboratory, Nakfa Hospital, Nakfa ...
Mengistu ST +6 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Influence of Wind and Basin Eddies in Controlling Sea Level Variations in the Coastal Red Sea
, 2015 Sea level variations in the central Red Sea coastal zone span a range of roughly 1.2 m. Though relatively small, these water level changes can significantly impact the environment over the shallow reef tops prevalent in the central Red Sea, altering the ...
Nellayaputhenpeedika, Mohammedali +3 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Aquatic Invasions! A Menace to the West : Red-Eared Slider Species Guide
The Red-Eared Slider, also called the red-eared terrapin, is an American breed of turtle widely spread across the USA, and is quickly becoming an invasive species in many parts of the world.
Siemens, Tania
core
, 2016 'Today, over two billion people in developing countries live without any electricity. They lead lives of misery, walking miles every day for water and firewood, just to survive. What if there was an existing, viable technology, that when developed to its
Al Arifi, Nassir +3 more
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Scientific ReportsThe ability to identify individual animals can provide valuable insights into the behaviour, life history, survivorship, and demographics of wild populations. Photo-identification (photo-ID) uses unique natural markings to identify individuals and can be
Ashlie J. McIvor +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source