Results 151 to 160 of about 257,904 (307)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Molecular identification and biological activity of a red sea bacterial isolate. [PDF]

BMC Microbiol
Matar MM, Elkholy YN, Negm WA, Elfeky HH, Yassien MA.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An Unusually Deep Corallimorph Barren on a Remote Coral Reef in the South-Central Red Sea. [PDF]

Ecol Evol
Rich WA, Peinemann VN, Burt NJ, Coker DJ, Glanz JS, Berumen ML, Johnson MD, Fox MD.   +7 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Spatial variation in spawning timing for multi-species Acropora assemblages in the Red Sea

Sexual reproduction is a crucial process for reef building coral populations to maximize genetic diversity and recover from large scale disturbances. Mass spawning events by Acropora species represent critical opportunities for populations to persist ...
Goergen, Elizabeth, Yoder, Sol, Gallab, Ahmed, Ramirez Sanchez, Megan, Glanz, Jessica, Benzoni, Francesca, Stead, Alexander, Attalla, Tamer M., Cook, Nathan, Osman, Eslam Osama, Pereira, Pedro, Santoro, Erika P., Casartelli, Marco, Garcias-Bonet, Neus, El-Sadek, Islam, Suggett, David, Peixoto, Raquel S.   +16 more
core   +1 more source

Integrating spectral signatures and microbial profiling to differentiate diseased and healthy corals in the Red sea. [PDF]

Sci Rep
Khalifa AM, ElBaghdady KZ, Hamed MM, Mohammad AS, Khaled MA.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Bio-optical characterization in an ultra-oligotrophic region: the North central Red Sea

, 2015
Until recently, satellite-derived ocean color observations have been the only means of evaluating optical variability of the Red Sea. During a cruise in autumn 2014, we investigated the variability of Inherent Optical Properties (IOPs) in the North ...
Kheireddine, Malika, Jones, Burton
core  

Occurrence and concentration of caffeine and cadmium as micropollutants in the Red Sea coast, Egypt. [PDF]

Sci Rep
El-Sokkary SG, Abd El-Wakeil KF, Obuid-Allah AH.   +2 more
europepmc   +1 more source