Results 81 to 90 of about 4,287,168 (297)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Frequency Shifts of Spectral Lines Generated by Young's Pinhole Wave Scattering Upon a Quasi-Homogeneous Medium

IEEE Photonics Journal, 2017
Frequency shifts of light scattered from either a deterministic or random medium have shown great importance in remote sensing imaging applications, however, such scattering system which combines random scatterer with obstacles has not been specifically ...
Jia Li, Yuechun Shi
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

An unusual red‐edge excitation and time‐dependent Stokes shift in the single tryptophan mutant protein DD‐carboxypeptidase from Streptomyces: The role of dynamics and tryptophan rotamers [PDF]

, 2007
Giovanni Maglia, Abel Jonckheer, Marc De Maeyer, Jean‐Marie Frère, Yves Engelborghs   +4 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Symmetric Responses to Diet by Plumage Carotenoids in Violet-Sensitive Piciform–Coraciiform Birds

Diversity
Biological studies on symmetry can be expanded to consider red (longer wavelengths) and blue (shorter wavelengths) shifts as antisymmetries (opposite-pattern symmetries), which may arise from similar underlying causes (invariant process symmetries).
Robert Bleiweiss
doaj   +1 more source

Red Shift in Optical Excitations on Layered Copper Perovskites under Pressure: Role of the Orthorhombic Instability. [PDF]

Chemistry, 2023
Carrasco-Busturia D, Sánchez-Movellán I, Tygesen AS, Bhowmik A, García-Lastra JM, Aramburu JA, Moreno M.   +6 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A red-shifted fluorescent substrate for aldehyde dehydrogenase [PDF]

, 2014
Il Minn, Haofan Wang, Ronnie C. Mease, Youngjoo Byun, Xing Yang, Julia Wang, Steven D. Leach, Martin G. Pomper   +7 more
openalex   +1 more source

Discovery of red-shifting mutations in firefly luciferase using high-throughput biochemistry [PDF]

, 2023
Clair M. Colee, Nicole Oberlag, Marcell Simon, Owen Chapman, Lyndsey Flanagan, Edison S. Reid‐McLaughlin, Jordan A. Gewing‐Mullins, Synaida Maiche, Devi F. Patel, André R.O. Cavalcanti, Aaron M. Leconte   +10 more
openalex   +1 more source