Results 81 to 90 of about 5,802,458 (360)

Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity

open access: yesPLoS ONE, 2017
MCherry, the Discosoma sp. mushroom coral-derived monomeric red fluorescent protein (RFP), is a commonly used genetically encoded fluorophore for live cell fluorescence imaging.
Yi Shen   +4 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Enhanced UV-Reflection Facilitated a Shift in the Pollination System of the Red Poppy, Papaver rhoeas (Papaveraceae)

open access: yesPlants, 2020
Evolutionary change is considered a major factor influencing the invasion of new habitats by plants. Yet, evidence on how such modifications promote range expansion remains rather limited. Here we investigated flower color modifications in the red poppy,
Jaime Martínez-Harms   +6 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

Anomalous light shift through quantum jumps in quasi-resonant Rayleigh scattering

open access: yes, 2012
An anomalous light shift in the precession of a ground-state Zeeman coherence is observed: the Larmor frequency increases with the strength of a drive that is blue (red) detuned from a transition out of the lower (upper) energy level.
Barberis-Blostein, P.   +4 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Ground survey of red lechwe in the Linyanti swamps and Chobe floodplains, northern Botswana

open access: yesKoedoe: African Protected Area Conservation and Science, 2017
A ground survey of red lechwe was carried out in the Linyanti swamps and the Chobe floodplains of northern Botswana in the dry and wet seasons of 2012 and 2013, respectively.
Phemelo Gadimang, Gaseitsiwe S. Masunga
doaj   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Influence of metal (Ag, Cd, Cu)-doping on the optical properties of ZnO nanopowder: Variation of band gap [PDF]

open access: yesشیمی کاربردی روز, 2013
Metal doped ZnO (MZO, metal = Ag, Cd, Cu) with different metal ion doped concentrations were synthesized by sol-gel method. The structural and optical properties were characterized by UV–Vis spectroscopy and Fourier transform infrared (FT-IR).
Bordbar Maryam   +3 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

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