Results 101 to 110 of about 11,964,360 (256)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

DEMOCRACIA NO SUS, COMO ESTAMOS? UM DEBATE SOBRE A PARTICIPAÇÃO SOCIAL A PARTIR DA LITERATURA RECENTE

, 2016
O Sistema Único de Saúde (SUS) é forjado em meio ao paradigma de abertura democrática no Brasil na década de 80, no contexto de uma sociedade capitalista em transformação.
Lisiane Bôer Possa, Rafael Cerva Melo, Possa, Lisiane Bôer, Melo, Rafael Cerva   +3 more
core   +1 more source

Vivências da enchente: o brincar e a criatividade infantil com as telas

Psi Unisc
As redes sociais tornaram-se plataformas importantes para o compartilhamento de experiências pessoais durante eventos desafiadores. Cuidadores frequentemente utilizam essas plataformas para divulgar vídeos de seus filhos, incluindo conteúdos criados ...
Indianara Sehaparini, Fernanda Martins Marques, Sofia Sebben, Cailane Lawall, Marina Furlan de Oliveira Aguiar, Giana Bitencourt Frizzo   +5 more
doaj   +1 more source

Pediatric allergy and immunology for patients and parents: challenges of developing website and social network during COVID-19 pandemic in Brazil. [PDF]

Rev Paul Pediatr, 2023
Takao MMV, de Souza FS, Riccetto L, Evangelista-Poderoso R, Riccetto AGL, da Silva MTN.   +5 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Social support network and quality of life in multiple sclerosis patients

Arquivos de Neuro-Psiquiatria
Objective To analyse the relationship between the social support network (SSN) and health related quality of life (HRQOL) in multiple sclerosis (MS) patients. Methods The sample comprised 150 consecutive MS patients attending our MS clinic.
David Castro Costa, Maria José Sá, José Manuel Calheiros   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Participação da rede social significativa de mulheres que vivem e convivem com o HIV no enfrentamento da soropositividade [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Psicologia, Florianópolis, 2011O recebimento da notícia diagnóstica, o aparecimento de sintomas e a aderência ao tratamento ...
Orlandi, Renata
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source