Results 41 to 50 of about 8,653,099 (253)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Redox-Neutral Synthesis of Sulfilimines through the S‑Alkylation of Sulfenamides

, 2023
In this work, we developed a metal-free and redox-neutral strategy for the selective S-alkylation of sulfenamides under basic conditions to yield sulfilimines. The key step involves the resonance between bivalent nitrogen-centered anions, generated after
Xinyu Xu (396786), Xunbo Lu, Kaiyuan Yang, Kaiyuan Yang (135297), Guoling Huang, Xinyu Xu, Xunbo Lu (6065717), Guoling Huang (9435421)   +7 more
core   +1 more source

Sedimentary genesis of the lower Triassic Dongping Mn deposit in South China: insights from low organic matter enrichment

Frontiers in Earth Science
The genetic mechanism of the Lower Triassic Dongping carbonate-hosted Mn deposit in South China remains debated, particularly regarding depositional redox conditions and the role of organic matter in Mn carbonate formation.
Peng Long, Peng Long, Tao Long, Rong-Zhi Li, Da-Qing Ding, Xin-Hong Jiang, Yi Zhang, Ling-Nan Zhao, Qin Huang, Sha Jiang, Sha Jiang, Chengying Xie   +11 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

The redox-sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes [PDF]

, 2008
Shaikhali J, Heiber I, Seidel T, et al. The redox-sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes. BMC Plant Biology.
Thorsten Seidel, Birkmann Stefan, Hiltscher, Heiko, Baier Margarete, Shaikhali, Jehad, Birkmann, Stefan, Heiber Isabelle, Stroeher, Elke, Dietz Karl-Josef, Karl-Josef Dietz, Baier, Margarete, Margarete Baier, Heiber, Isabelle, Hiltscher Heiko, Shaikhali Jehad, Heiko Hiltscher, Dietz, Karl-Josef, Isabelle Heiber, Elke Ströher, Seidel Thorsten, Jehad Shaikhali, Seidel, Thorsten, Ströher Elke, Stefan Birkmann   +23 more
core   +1 more source

Geochemical Constraints on Organic Matter Enrichment in Lower Cambrian Qiongzhusi Marine Shales of the Deyang–Anyue Extensional Trough, Southern Sichuan Basin

Journal of Marine Science and Engineering
The Lower Cambrian Qiongzhusi Formation has emerged as a major shale-gas target in the Sichuan Basin, but controls on organic matter enrichment across extensional-trough settings remain poorly understood. We compare two stratigraphically correlated wells,
Kailin Tong, Wenping Liu, Jiaxin Wang, Xunxi Qiu, Zhen Wang, Jianting Yao, Siyi Fu, Yixin Dong, Yijiang Zhong, Jiale Tang, Rongting Zheng   +10 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression [PDF]

, 2012
Klein P, Seidel T, Stöcker B, Dietz K-J. The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression. Frontiers in Plant Science.
Thorsten Seidel, Dietz, Karl-Josef, Benedikt eStöcker, Benedikt Stöcker, Peter eKlein, Klein, Peter, Thorsten eSeidel, Peter Klein, Karl-Josef Dietz, Seidel, Thorsten, Stöcker, Benedikt, Karl-Josef eDietz   +11 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Principles in redox signaling: from chemistry to functional significance. [PDF]

, 2013
Reactive oxygen and nitrogen species are currently considered not only harmful byproducts of aerobic respiration but also critical mediators of redox signaling.
RIGOBELLO, MARIA PIA, BINDOLI, ALBERTO, Bindoli A, Rigobello MP   +3 more
core   +1 more source