Results 41 to 50 of about 688,031 (301)

Feasible Cluster Model Method for Simulating the Redox Potentials of Laccase CueO and Its Variant

Frontiers in Bioengineering and Biotechnology, 2022
Laccases are regarded as versatile green biocatalysts, and recent scientific research has focused on improving their redox potential for broader industrial and environmental applications.
Qixuan Jiang, Ziheng Cui, Ren Wei, Kaili Nie, Haijun Xu, Luo Liu   +5 more
doaj   +1 more source

Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes [PDF]

, 2016
Herein, the thiol pKa and standard redox potential of mycothiol, the major low molecular weight thiol cofactor in the actinomycetes, are reported.
Hamilton, Chris James, Messens, Joris, Sharma, Sunil V, Van Laer, Koen   +3 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Diquat Derivatives: Highly Active, Two-Dimensional Nonlinear Optical Chromophores with Potential Redox Switchability [PDF]

, 2010
In this article, we present a detailed study of structure−activity relationships in diquaternized 2,2′-bipyridyl (diquat) derivatives. Sixteen new chromophores have been synthesized, with variations in the amino electron donor substituents, π-conjugated ...
Abbotto A., Akdas-Kilig H., Alain V., Averseng F., Benjamin J. Coe, Bosshard Ch., Boubekeur-Lecaque L., Bruce S. Brunschwig, Brunschwig B. S., Bublitz G. U., Campo J., Cariati E., Champagne B., Cho B. R., Cifuentes M. P., Clays K., Clays K., Clays K., Clays K., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Coe B. J., Cui Y.-Z., Dhenaut C., Di Bella S., Di Bella S., Di Bella S., Ferguson, B., Figi H., Franz E., Geis W., Gillaizeau-Gauthier I., Heesink G. J. T., Hendrickx E., Hennrich G., Hilton A., Inge Asselberghs, Isborn C. M., James A. Harris, Jang S.-R., Javier Garín, Jeong M.-Y., Jesús Orduna, John Fielden, Kaino T., Kawase K., Kawase K., Kim H. M., Kim H. S., Kim H. S., Knoch F., Koen Clays, Kuzuya M., Kuzyk M. G., Kuzyk M. G., Kwon O., Lacroix P. G., Le Bouder T., Le Floc’h V., Lee O.-K., Li H.-P., Li H.-P., Lindner E., Liu C.-G., Liu Y., Madeleine Helliwell, Malaun M., Marder S. R., Marder S. R., Marder S. R., Marder S. R., Maury O., Maury O., McDonagh A. M., McEntee J., Meshulam G., Miles R. E., Mohan Kumar R., Mori Y., Moylan C. R., Muhammad S., Nalwa H. S., Nunzi F., Olbrechts G., Olbrechts G., Ostroverkhov V., Oudar J. L., Oudar J. L., Papadopoulos M. G., Powell C. E., Rigamonti L., Ruiz B., Ruiz B., Schneider A., Schneider A., Simon P. Foxon, Sohma S., Sporer C., Tai O. Y.-H., Taniuchi T., Taniuchi T., Vance F. W., Vance F. W., Verbiest T., Weyland T., Willetts A., Wolff J. J., Wolff J. J., Woodford J. N., Wortmann R., Wortmann R., Xu X.-L., Yang M.-L., Yang Z., Yang Z., Yang Z., Yitzchaik S., Zhou Y.-F., Zrig S., Zyss J., Zyss J.   +131 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Abiotic reductive dehalogenation of pharmaceuticals with naturally occurring redox mediators

Environmental Advances
This preliminary study investigated whether a reductive dehalogenation of brominated, chlorinated and fluorinated pharmaceuticals is possible using redox mediators as found for iodinated x-ray contrast media.
Kerstin Gerundt, Jörg Lewandowski, Anke Putschew   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The relationship between dissolved organic carbon and hydro-climatic factors in peat-muck soil

Journal of Water and Land Development, 2015
The object of this study was the concentration of dissolved organic carbon (DOC) in soil solution related to groundwater table, soil temperature, moisture, redox potential and intensive storm rain and their changes during ten years (2001–2010).
Jaszczyński Jacek
doaj   +1 more source