Results 101 to 110 of about 1,843,340 (266)

Reduced-Order Model Based on Neural Network of Roll Bending

open access: yesApplied Sciences
Effective real-time control systems require fast and accurate models. The roll bending models presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Generative design of graded metamaterial arrays for dynamic response modulation

open access: yesMaterials & Design
Mechanical metamaterials (MMs) are micro-structured systems that have long attracted research as well as application interests due to their exotic dynamic functionalities and properties not seen in ordinary materials.
Weidi Wang   +2 more
doaj   +1 more source

A multiparametric advection-diffusion reduced-order model for molecular transport in scaffolds for osteoinduction. [PDF]

open access: yesBiomech Model Mechanobiol, 2022
Muixí A   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Koopman Reduced-Order Modeling with Confidence Bounds

open access: yesSIAM Journal on Applied Dynamical Systems
This paper introduces a reduced order modeling technique based on Koopman operator theory that gives confidence bounds on the model's predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced order model is constructed using a finite number of Koopman eigenvalues and modes, while the rest of spectrum is ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire   +2 more sources

Development of Reduced Order Model for Steady State Flow Field in Two-dimensional Lower Plenum

open access: yesYuanzineng kexue jishu
In the field of reactor thermal-hydraulics, system thermal-hydraulic codes have been widely employed to quickly determine the global response characteristics of the primary system.
SHANG He1, PENG Minjun1, 2, XIA Genglei1, 2, , ZHANG Shiqi1, ZHU Shijie1
doaj   +1 more source

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