Results 121 to 130 of about 26,791,362 (287)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Reduced-Order Model Based on Neural Network of Roll Bending

Applied Sciences
Effective real-time control systems require fast and accurate models. The roll bending models presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

Real time reduced order model for angiography fractional flow reserve. [PDF]

Comput Methods Programs Biomed, 2022
Hashemi J, Patel B, Chatzizisis YS, Kassab GS.   +3 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Development of a force identification method using system-level measurements with component-level reduced-order modeling

Nuclear Engineering and Technology
The accurate estimation of excitation forces is essential for maintaining the structural integrity of dynamic systems. However, direct measurement of excitation forces is often infeasible in practical scenarios.
Hyeongyeong Jin, Seunghun Baek
doaj   +1 more source

A multiparametric advection-diffusion reduced-order model for molecular transport in scaffolds for osteoinduction. [PDF]

Biomech Model Mechanobiol, 2022
Muixí A, Zlotnik S, Calvet P, Espanol M, Lodoso-Torrecilla I, Ginebra MP, Díez P, García-González A.   +7 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Reduced-Order Model of a Time-Trial Cyclist Helmet for Aerodynamic Optimization Through Mesh Morphing and Enhanced with Real-Time Interactive Visualization

Fluids
Aerodynamics is a key factor in time-trial cycling. Over the years, various aspects have been investigated, including positioning, clothing, bicycle design, and helmet shape.
E. Di Meo, A. Lopez, C. Groth, M. E. Biancolini, P. P. Valentini   +4 more
doaj   +1 more source

Data-driven reduced order model and simplicial homology global optimization for reliability analysis and application. [PDF]

Heliyon, 2022
Zhao H, Wang M, Chang X.
europepmc   +1 more source

Koopman Reduced-Order Modeling with Confidence Bounds

SIAM Journal on Applied Dynamical Systems
Abstract. This paper introduces a reduced-order modeling technique based on Koopman operator theory that gives confidence bounds on the model’s predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced-order model is constructed using a finite number of Koopman eigenvalues and modes, while ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire   +2 more sources