Results 111 to 120 of about 6,124,322 (291)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Deep-Learning-Based Reduced-Order Model for Power Generation Capacity of Flapping Foils. [PDF]

Biomimetics (Basel), 2023
Saeed A, Farooq H, Akhtar I, Tariq MA, Khalid MSU.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Multi-fidelity reduced-order surrogate modelling

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
High-fidelity numerical simulations of partial differential equations (PDEs) given a restricted computational budget can significantly limit the number of parameter configurations considered and/or time window evaluated. Multi-fidelity surrogate modelling aims to leverage less accurate, lower-fidelity models that are computationally ...
Paolo Conti, Mengwu Guo, Andrea Manzoni, Attilio Frangi, Steven L. Brunton, J. Nathan Kutz   +5 more
openaire   +5 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Reduced-Order Model Based on Neural Network of Roll Bending

Applied Sciences
Effective real-time control systems require fast and accurate models. The roll bending models presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

Construction of a reduced-order model based on tensor decomposition and its application to airbag deployment simulations. [PDF]

Sci Rep, 2023
Sasagawa T, Tanaka M.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Generative design of graded metamaterial arrays for dynamic response modulation

Materials & Design
Mechanical metamaterials (MMs) are micro-structured systems that have long attracted research as well as application interests due to their exotic dynamic functionalities and properties not seen in ordinary materials.
Weidi Wang, Willoughby Cheney, Alireza V. Amirkhizi   +2 more
doaj   +1 more source

Real time reduced order model for angiography fractional flow reserve. [PDF]

Comput Methods Programs Biomed, 2022
Hashemi J, Patel B, Chatzizisis YS, Kassab GS.   +3 more
europepmc   +1 more source