Koopman Reduced-Order Modeling with Confidence Bounds
SIAM Journal on Applied Dynamical SystemsThis paper introduces a reduced order modeling technique based on Koopman operator theory that gives confidence bounds on the model's predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced order model is constructed using a finite number of Koopman eigenvalues and modes, while the rest of spectrum is ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Development of Reduced Order Model for Steady State Flow Field in Two-dimensional Lower Plenum
Yuanzineng kexue jishuIn the field of reactor thermal-hydraulics, system thermal-hydraulic codes have been widely employed to quickly determine the global response characteristics of the primary system.
SHANG He1, PENG Minjun1, 2, XIA Genglei1, 2, , ZHANG Shiqi1, ZHU Shijie1
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A reduced-order model of the spine to study pediatric scoliosis. [PDF]
Biomech Model Mechanobiol, 2021 Neelakantan S, Purohit PK, Pasha S.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Generative design of graded metamaterial arrays for dynamic response modulation
Materials & DesignMechanical metamaterials (MMs) are micro-structured systems that have long attracted research as well as application interests due to their exotic dynamic functionalities and properties not seen in ordinary materials.
Weidi Wang +2 more
doaj +1 more source
An improved reduced-order model for pressure drop across arterial stenoses. [PDF]
PLoS One, 2021 Lyras KG, Lee J.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Numerical Prediction of Two-Phase Flow through a Tube Bundle Based on Reduced-Order Model and a Void Fraction Correlation. [PDF]
Entropy (Basel), 2021 Dubot C +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source