Results 71 to 80 of about 26,791,362 (287)

A reduced order model to assist welding parameter setup

Mechanics & Industry
This article demonstrates the time saving in industrial process setup using numerical reduced order modelling (ROM). The numerical simulations may supply useful information to design manufacturing processes but are often time consuming and then not ...
Le Guennec Yves, Morville Simon
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reduced Order Modeling and Sliding Mode Control of Active Magnetic Bearing

IEEE Access, 2019
Due to the accelerated growth in the field of power electronics and controller design techniques, the usage of the active magnetic bearing has picked up in industries. Active magnetic bearing helps the rotor to rotate freely without any physical contact.
Sudipta Saha, Syed Muhammad Amrr, Mashuq Un Nabi, Atif Iqbal   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reduced order models based on pod method for schrödinger equations

Mathematical Modelling and Analysis, 2013
Reduced-order models (ROM) are developed using the proper orthogonal decomposition (POD) for one dimensional linear and nonlinear Schrödinger equations. The main aim of this paper is to study the accuracy and robustness of the ROM approximations.
Gerda Jankevičiutė, Teresė Leonavičienė, Raimondas Čiegis, Andrej Bugajev   +3 more
doaj   +1 more source

An orifice shape-based reduced order model of patient-specific mitral valve regurgitation

Engineering Applications of Computational Fluid Mechanics, 2021
Mitral valve regurgitation (MR) is one of the most prevalent valvular heart diseases. Its quantitative assessment is challenging but crucial for treatment decisions.
J. Franz, K. Czechowicz, I. Waechter-Stehle, F. Hellmeier, F. Razafindrazaka, M. Kelm, J. Kempfert, A. Meyer, G. Archer, J. Weese, R. Hose, T. Kuehne, L. Goubergrits   +12 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Fractional-Order Model-Assisted Reduced-Order ADRC for Photoelectric Stabilized Platforms

IEEE Access
To enhance the dynamic performance and disturbance rejection capability of photoelectric stabilized platforms, this study proposes a Fractional-Order Model-assisted Reduced-order Linear Active Disturbance Rejection Control (FO-MRLADRC) algorithm.
Guoyu Lin, Jiangong Wang, Hongwei Di, Xu Chen   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source