Results 71 to 80 of about 395,716 (259)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Neuro-Fuzzy Network-Based Reduced-Order Modeling of Transonic Aileron Buzz
Aerospace, 2020 In the present work, a reduced-order modeling (ROM) framework based on a recurrent neuro-fuzzy model (NFM) that is serial connected with a multilayer perceptron (MLP) neural network is applied for the computation of transonic aileron buzz.
Rebecca Zahn, Christian Breitsamter
doaj +1 more source
KROM: Kernelized Reduced Order Modeling
CoRRWe propose KROM, a kernel-based reduced-order framework for fast solution of nonlinear partial differential equations. KROM formulates PDE solution as a minimum-norm (Gaussian-process) recovery problem in an RKHS, and accelerates the resulting kernel solves by sparsifying the precision matrix via sparse Cholesky factorization.
Aras Bacho, Jonghyeon Lee, Houman Owhadi
openaire +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Reduced Order Modeling of Composite Laminates Through Solid-Shell Coupling
Journal of Aerospace Technology and Management, 2017 Composite laminates display a complex mechanical behavior due to their microstructure, with a through-thickness variation of the displacement and stress fields that depends on the fiber orientation in each layer. Aiming to develop reduced-order numerical
Gigliola Salerno +2 more
doaj
Journal of Advances in Modeling Earth SystemsInvestigating the role of clouds and precipitation in the Earth system necessitates microphysical schemes capable of accurately describing the evolution of hydrometeor particle size distribution (PSD), while maintaining low computational costs ...
Kang‐En Huang +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Machine Learning: Science and TechnologyWhile many phenomena in physics and engineering are formally high-dimensional, their long-time dynamics often live on a lower-dimensional manifold. The present work introduces an autoencoder framework that combines implicit regularization with internal ...
Kevin Zeng +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source