Results 101 to 110 of about 4,521,373 (282)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reduced Order Modeling of an Industrial Feeder Model

IFAC Proceedings Volumes, 2003
Models of glaes furnaces are described by a set of nonlinear partial differential equâtioris which govern the mass, momentum and energy balances and a numberof non-linear functions of the independent scalais which describe the dependent variables like viscosities and densities in a fluid.
Astrid, P., Weiland, S., Twerda, A.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Using the Neumann series expansion for assembling Reduced Order Models

Applied and Computational Mechanics, 2014
An efficient method to remove the limitation in selecting the master degrees of freedom in a finite element model by means of a model order reduction is presented.
Nasisi S., Valášek M., Vampola T.
doaj  

Accelerated construction of projection-based reduced-order models via incremental approaches

Advanced Modeling and Simulation in Engineering Sciences
We present an accelerated greedy strategy for training of projection-based reduced-order models for parametric steady and unsteady partial differential equations.
Eki Agouzal, Tommaso Taddei
doaj   +1 more source

Model Error, Information Barriers, State Estimation and Prediction in Complex Multiscale Systems

Entropy, 2018
Complex multiscale systems are ubiquitous in many areas. This research expository article discusses the development and applications of a recent information-theoretic framework as well as novel reduced-order nonlinear modeling strategies for ...
Andrew J. Majda, Nan Chen
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Nonlinear acoustics in brass instruments using 2D complex modal bases

Acta Acustica
The modelling approach presented here aims at developing accurate, yet computationally efficient, numerical models of brass instrument resonators including nonlinear propagation, viscothermal losses and radiation effects in 2D axisymmetric domains.
Soares Filipe, Cochelin Bruno, Freour Vincent, Vergez Christophe, Arimoto Keita   +4 more
doaj   +1 more source