Results 121 to 130 of about 19,884,535 (281)
Accelerated construction of projection-based reduced-order models via incremental approaches
Advanced Modeling and Simulation in Engineering SciencesWe present an accelerated greedy strategy for training of projection-based reduced-order models for parametric steady and unsteady partial differential equations.
Eki Agouzal, Tommaso Taddei
doaj +1 more source
Reduced joint models for damping design of multi-jointed structures [PDF]
, 2014 − Design of damping in multi-jointed structures is studied here. − Dissipation sources are viscoelastic behavior and contact/friction at joints interfaces. − Reduction on meta-models of nonlinear joints models is investigated.
BALMES, Etienne +2 more
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Consistency of the full and reduced order models for evolve-filter-relax regularization of convection-dominated, marginally-resolved flows. [PDF]
Int J Numer Methods Eng, 2022 Strazzullo M +4 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Koopman Reduced-Order Modeling with Confidence Bounds
SIAM Journal on Applied Dynamical SystemsAbstract. This paper introduces a reduced-order modeling technique based on Koopman operator theory that gives confidence bounds on the model’s predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced-order model is constructed using a finite number of Koopman eigenvalues and modes, while ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Development of mechanistic reduced order models (ROMs)for glidant and lubricant effects in continuous manufacturing of pharmaceutical solid-dosage forms. [PDF]
ESCAPE, 2022 Bachawala S, Gonzalez M.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source