Results 61 to 70 of about 389,752 (273)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Increased inter-colony fusion rates are associated with reduced COI haplotype diversity in an invasive colonial ascidian Didemnum vexillum

, 2012
Considerable progress in our understanding of the population genetic changes associated with biological invasions has been made over the past decade. Using selectively neutral loci, it has been established that reductions in genetic diversity, reflecting
Fidler, Andrew, Kirsty F Smith, Yasunori Saito, S Craig Cary, Fidler, Andrew E., Andrew E. Fidler (186099), Gemmill, CEC, Lauren Stefaniak, Saito, Yasunori, Gemmill, Chrissen E.C., Smith, KF, Kirsty F. Smith (186082), Lauren Stefaniak (186086), Saito, Y, Chrissen E C Gemmill, Smith, Kirsty Fiona, Yasunori Saito (186090), Chrissen E. C. Gemmill (186094), Cary, S. Craig, Cary, SC, Stefaniak, Lauren, S. Craig Cary (133811), Andrew E Fidler, Stefaniak, L   +23 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Pengembangan Metode Quad Smoothness Reduced Difference Expansion Untuk Steganography Pada Audio [PDF]

, 2017
Steganography adalah salah satu bagian dari teknik penyembunyian data. Tujuan utama dari steganography adalah untuk menjaga orang lain agar tidak mengetahui informasi rahasia yang disembunyikan.
Nugroho, Danang Adi
core  

Evaluation of pain intensity and airway changes in non-growing patients treated by MARPE with and without micro-osteoperforation: a randomized clinical trial

BMC Oral Health
Trial design Parallel. Objectives To assess the effect of mini-screw assisted rapid palatal expansion (MARPE) with/without micro-osteoperforation (MOP) on the airway and pain intensity in non-growing patients with maxillary transverse deficiency.
Moataz Elshehaby, Nehal Fouad Albelasy, Mohamed A. Elbialy, Ahmad Mohammed Hafez, Yasser Lotfy Abdelnaby   +4 more
doaj   +1 more source

Inpatient Trauma Mortality after Implementation of the Affordable Care Act in Illinois

Western Journal of Emergency Medicine, 2018
Introduction: Illinois hospitals have experienced a marked decrease in the number of uninsured patients after implementation of the Affordable Care Act (ACA).
Paul L. Weygandt, Scott M. Dresden, Emilie S. Powell, Joe Feinglass   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Optimizing orthodontic treatment for delayed eruption of permanent anterior teeth: A prospective study using a modified appliance

Saudi Dental Journal
Delayed permanent anterior teeth eruption, accompanied by insufficient space in the dental arch, presents a significant challenge during mixed dentition.
Nataliia Malashenko, Kostiantyn Lykhota, Larysa Dakhno   +2 more
doaj   +1 more source