Results 71 to 80 of about 7,597,003 (252)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Volume changes of gypsum-based lightweight mortar during the heating process

Materials Research Express
Gypsum-based lightweight mortar undergoes dehydration of gypsum when subjected to changes in external temperature, which macroscopically manifests as a change in volume. Based on the dehydration kinetics of gypsum, the phase transition during dehydration
Xuebing Wang, Yexue Li, Guanting Wen
doaj   +1 more source

Propagation law of hydraulic-induced fractures in directional hydraulic fracturing with prefabricated cracks based on phase-field method

Yantu gongcheng xuebao
To investigate the propagation and evolution laws of induced cracks in rocks under directional hydraulic fracturing, a phase-field model is developed.
LIANG Xin 1, 2 , HOU Peng 3 , XUE Yi 1, 2, LIU Jia 1, 2, GAO Feng 4
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Blunt versus sharp expansion of uterine incision during lower segment cesarean section

BMC Pregnancy and Childbirth
Background The method of uterine incision expansion throughout lower segment cesarean section (LSCS) may impact intraoperative blood loss and surgical outcomes.
Ahmed M. Zeinhom, Sherif M. Habib, Ahmed Eraky Atta, Ahmed M. Essam   +3 more
doaj   +1 more source

The effect of topically applied tissue expanders on radial forearm skin pliability: A prospective self-controlled study

Journal of Otolaryngology - Head and Neck Surgery, 2014
Background The use of pre-operatively applied topical tissue expansion tapes have previously demonstrated increased rates of primary closure of radial forearm free flap donor sites.
Jeffson Chung, James P Bonaparte, Michael Odell, Martin Corsten   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prevention of contrast-induced acute kidney injury: is simple oral hydration similar to intravenous? A systematic review of the evidence.

PLoS ONE, 2013
BackgroundPre-procedural intravenous fluid administration is an effective prophylaxis measure for contrast-induced acute kidney injury. For logistical ease, the oral route is an alternative to the intravenous.
Swapnil Hiremath, Ayub Akbari, Wael Shabana, Dean A Fergusson, Greg A Knoll   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source