Results 131 to 140 of about 26,492,778 (291)

Data-driven reduced order model and simplicial homology global optimization for reliability analysis and application. [PDF]

Heliyon, 2022
Zhao H, Wang M, Chang X.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Development of Reduced Order Model for Steady State Flow Field in Two-dimensional Lower Plenum

Yuanzineng kexue jishu
In the field of reactor thermal-hydraulics, system thermal-hydraulic codes have been widely employed to quickly determine the global response characteristics of the primary system.
SHANG He1, PENG Minjun1, 2, XIA Genglei1, 2, , ZHANG Shiqi1, ZHU Shijie1
doaj   +1 more source

Semi-mechanistic reduced order model of pharmaceutical tablet dissolution for enabling Industry 4.0 manufacturing systems. [PDF]

Int J Pharm, 2023
Ferdoush S, Gonzalez M.
europepmc   +1 more source

Koopman Reduced-Order Modeling with Confidence Bounds

SIAM Journal on Applied Dynamical Systems
This paper introduces a reduced order modeling technique based on Koopman operator theory that gives confidence bounds on the model's predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced order model is constructed using a finite number of Koopman eigenvalues and modes, while the rest of spectrum is ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Generative design of graded metamaterial arrays for dynamic response modulation

Materials & Design
Mechanical metamaterials (MMs) are micro-structured systems that have long attracted research as well as application interests due to their exotic dynamic functionalities and properties not seen in ordinary materials.
Weidi Wang, Willoughby Cheney, Alireza V. Amirkhizi   +2 more
doaj   +1 more source

A reduced-order model of the spine to study pediatric scoliosis. [PDF]

Biomech Model Mechanobiol, 2021
Neelakantan S, Purohit PK, Pasha S.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An improved reduced-order model for pressure drop across arterial stenoses. [PDF]

PLoS One, 2021
Lyras KG, Lee J.
europepmc   +1 more source