Results 131 to 140 of about 1,914,780 (311)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Reduced-Order Model Based on Neural Network of Roll Bending

Applied Sciences
Effective real-time control systems require fast and accurate models. The roll bending models presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

Real time reduced order model for angiography fractional flow reserve. [PDF]

Comput Methods Programs Biomed, 2022
Hashemi J, Patel B, Chatzizisis YS, Kassab GS.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Generative design of graded metamaterial arrays for dynamic response modulation

Materials & Design
Mechanical metamaterials (MMs) are micro-structured systems that have long attracted research as well as application interests due to their exotic dynamic functionalities and properties not seen in ordinary materials.
Weidi Wang, Willoughby Cheney, Alireza V. Amirkhizi   +2 more
doaj   +1 more source

Data-driven reduced order model and simplicial homology global optimization for reliability analysis and application. [PDF]

Heliyon, 2022
Zhao H, Wang M, Chang X.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A multiparametric advection-diffusion reduced-order model for molecular transport in scaffolds for osteoinduction. [PDF]

Biomech Model Mechanobiol, 2022
Muixí A, Zlotnik S, Calvet P, Espanol M, Lodoso-Torrecilla I, Ginebra MP, Díez P, García-González A.   +7 more
europepmc   +1 more source

Nonlinear Parameter Space and Model Order Reductions enhanced by scientific machine learning

, 2023
Two of the main critical issues of model order reduction are the curse of dimensionality and the slow Kolmogorov n-width decay. With this thesis we want to provide novel methodologies that can ameliorate them: for the former we develop nonlinear ...
ROMOR, FRANCESCO
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source