Results 111 to 120 of about 1,914,780 (311)

Applicability Analysis of Reduced-Order Methods with Proper Orthogonal Decomposition for Neutron Diffusion in Molten Salt Reactor

Energies
The high-dimensional integral–differential nature of the neutron transport equation and the complexity of nuclear reactors result in high computational costs.
Zhengyang Zhou, Ming Lin, Maosong Cheng, Yuqing Dai, Xiandi Zuo   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Vortex-induced vibration of catenary riser: reduced-order modeling and lock-in analysis using wake oscillator

, 2009
A new reduced-order model capable of analyzing the vortex-induced vibration of catenary riser in the ocean current has been developed. This semi analytical-numerical approach is versatile and allows for a significant reduction in computational effort for
, KTP (Funder), O'Brien, P., KTP (Funder), Wiercigrocha, M., Younger, R., Srinil, N.   +5 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reduced order model of flows by time-scaling interpolation of DNS data

Advanced Modeling and Simulation in Engineering Sciences, 2018
A new reduced order model (ROM) is proposed here for reconstructing super-critical flow past circular cylinder and lid driven cavity using time-scaling of vorticity data directly.
Tapan K. Sengupta, Lucas Lestandi, S. I. Haider, Atchyut Gullapalli, Mejdi Azaïez   +4 more
doaj   +1 more source

Reduced basis method for the Smagorinsky model [PDF]

, 2016
We present a reduced basis Smagorinsky model. This model includes a non-linear eddy diffusion term that we have to treat in order to solve efficiently our reduced basis model.
Chacón Rebollo, Tomás, Gómez Mármol, María Macarena, Delgado Ávila, Enrique   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Sliding Mode Control Design via Reduced Order Model Approach

, 2006
The paper presents the design of sliding mode control for the higher order system via reduced order model. It has been shown that a sliding mode control designed for the reduced order model gives similar performance for the higher order system.
S. Janardhanan, B. Bandyopadhyay, Abera, Alemayehu G/Egziabher, Janardhanan, S., Alemayehu G/Egziabher Abera, Bandyopadhyay, B.   +5 more
core   +3 more sources