Results 101 to 110 of about 1,853,525 (263)

Real time reduced order model for angiography fractional flow reserve. [PDF]

Comput Methods Programs Biomed, 2022
Hashemi J, Patel B, Chatzizisis YS, Kassab GS.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Reduced-Order Model Based on Neural Network of Roll Bending

Applied Sciences
Effective real-time control systems require fast and accurate models. The roll bending models presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

Data-driven reduced order model and simplicial homology global optimization for reliability analysis and application. [PDF]

Heliyon, 2022
Zhao H, Wang M, Chang X.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Development of a force identification method using system-level measurements with component-level reduced-order modeling

Nuclear Engineering and Technology
The accurate estimation of excitation forces is essential for maintaining the structural integrity of dynamic systems. However, direct measurement of excitation forces is often infeasible in practical scenarios.
Hyeongyeong Jin, Seunghun Baek
doaj   +1 more source

A multiparametric advection-diffusion reduced-order model for molecular transport in scaffolds for osteoinduction. [PDF]

Biomech Model Mechanobiol, 2022
Muixí A, Zlotnik S, Calvet P, Espanol M, Lodoso-Torrecilla I, Ginebra MP, Díez P, García-González A.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reduced-Order Model of a Time-Trial Cyclist Helmet for Aerodynamic Optimization Through Mesh Morphing and Enhanced with Real-Time Interactive Visualization

Fluids
Aerodynamics is a key factor in time-trial cycling. Over the years, various aspects have been investigated, including positioning, clothing, bicycle design, and helmet shape.
E. Di Meo, A. Lopez, C. Groth, M. E. Biancolini, P. P. Valentini   +4 more
doaj   +1 more source

Semi-mechanistic reduced order model of pharmaceutical tablet dissolution for enabling Industry 4.0 manufacturing systems. [PDF]

Int J Pharm, 2023
Ferdoush S, Gonzalez M.
europepmc   +1 more source