Results 81 to 90 of about 1,853,525 (263)

Reduced-Order Computational Model for Low-Frequency Dynamics of Automobiles

Advances in Mechanical Engineering, 2013
A reduced-order model is constructed to predict, for the low-frequency range, the dynamical responses in the stiff parts of an automobile constituted of stiff and flexible parts.
A. Arnoux, C. Soize, A. Batou, L. Gagliardini   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Reduced Order Model of the Thermal Profile of the Rolls for the Real-Time Control System

Energies
Effective real-time control systems require fast and accurate models. The thermal profile models of the rolls presented in this paper are proposed for a real-time control system for the design of the rolling schedule.
Dmytro Svyetlichnyy
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Applicability Analysis of Reduced-Order Methods with Proper Orthogonal Decomposition for Neutron Diffusion in Molten Salt Reactor

Energies
The high-dimensional integral–differential nature of the neutron transport equation and the complexity of nuclear reactors result in high computational costs.
Zhengyang Zhou, Ming Lin, Maosong Cheng, Yuqing Dai, Xiandi Zuo   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Calibrated Intrusive Reduced-Order Model of Burgers’ Equation Using a Combination of Proper Orthogonal Decomposition and LSTM Deep Learning Algorithm

Modelling
Modelling plays a critical role in many engineering applications. Partial differential equations (PDEs) are ubiquitous, describing various physical phenomena such as fluid flow, electromagnetism, and quantum mechanics.
Mina Golzar, Mohammad Kazem Moayyedi, Faranak Fotouhi-Ghazvini, Maryam Vahabi, Hossein Fotouhi   +4 more
doaj   +1 more source

A Generalized State-Space Aeroservoelastic Model Based on Tangential Interpolation

Aerospace, 2019
In this work, a new approach for the generation of a generalized state-space aeroservoelastic model based on tangential interpolation is presented.
David Quero, Pierre Vuillemin, Charles Poussot-Vassal   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source