Results 61 to 70 of about 1,914,780 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A reduced order model for fission gas diffusion in columnar grains

open access: yesNuclear Engineering and Technology, 2023
In fast reactors, restructuring of the fuel micro-structure driven by high temperature and high temperature gradient can cause the formation of columnar grains.
D. Pizzocri   +6 more
doaj   +1 more source

Reduced-Order Modeling of the Fluidic Pinball [PDF]

open access: yes, 2019
The fluidic pinball is a geometrically simple flow configuration with three rotating cylinders on the vertex of an equilateral triangle. Yet, it remains physically rich enough to host a range of interacting frequencies and to allow testing of control laws within minutes on a laptop.
Pastur, Luc   +3 more
openaire   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Reduced order and surrogate models for gravitational waves

open access: yesLiving Reviews in Relativity, 2022
AbstractWe present an introduction to some of the state of the art in reduced order and surrogate modeling in gravitational-wave (GW) science. Approaches that we cover include principal component analysis, proper orthogonal (singular value) decompositions, the reduced basis approach, the empirical interpolation method, reduced order quadratures, and ...
Manuel Tiglio, Aarón Villanueva
openaire   +3 more sources

CFD-based comfort parameter evaluation of a flow vectoring air vent system for car cabins using a reduced order model [PDF]

open access: yes
This Computational Fluid Dynamics (CFD) study examines the comfort parameters of an innovative air vent concept for car cabin interiors using a Reduced Order Model (ROM) and Proper Orthogonal Decomposition (POD).
Wagner, Claus   +4 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Multi-Frequency Aeroelastic ROM for Transonic Compressors

open access: yesAerospace
The accurate prediction of the aeroelastic behavior of turbomachinery for aircraft propulsion poses a difficult yet fundamental challenge, since modern aircraft engines tend to adopt increasingly slender blades to achieve a higher aerodynamic efficiency,
Marco Casoni   +2 more
doaj   +1 more source

Estimating flow fields with reduced order models

open access: yesHeliyon, 2023
The estimation of fluid flows inside a centrifugal pump in realtime is a challenging task that cannot be achieved with long-established methods like CFD due to their computational demands. We use a projection-based reduced order model (ROM) instead.
Kamil David Sommer   +4 more
openaire   +4 more sources

Home - About - Disclaimer - Privacy