Results 111 to 120 of about 4,522,001 (282)

A Simple Matlab Code for Material Design Optimization Using Reduced Order Models. [PDF]

Materials (Basel), 2022
Kazakis G, Lagaros ND.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Automated generation of 0D and 1D reduced-order models of patient-specific blood flow. [PDF]

Int J Numer Method Biomed Eng, 2022
Pfaller MR, Pham J, Verma A, Pegolotti L, Wilson NM, Parker DW, Yang W, Marsden AL.   +7 more
europepmc   +1 more source

Multi-fidelity reduced-order surrogate modelling

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
High-fidelity numerical simulations of partial differential equations (PDEs) given a restricted computational budget can significantly limit the number of parameter configurations considered and/or time window evaluated. Multi-fidelity surrogate modelling aims to leverage less accurate, lower-fidelity models that are computationally ...
Paolo Conti, Mengwu Guo, Andrea Manzoni, Attilio Frangi, Steven L. Brunton, J. Nathan Kutz   +5 more
openaire   +5 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Pade-Type Model Reduction of Second-Order and Higher-Order Linear Dynamical Systems

, 2004
A standard approach to reduced-order modeling of higher-order linear dynamical systems is to rewrite the system as an equivalent first-order system and then employ Krylov-subspace techniques for reduced-order modeling of first-order systems.
Freund, Roland W.
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Design of Input Signal for System Identification of a Generic Fighter Configuration

Aerospace
This article investigates the design of time-accurate input signals in the angle-of-attack and pitch rate space to identify the aerodynamic characteristics of a generic triple-delta wing configuration at subsonic speeds.
Mehdi Ghoreyshi, Pooneh Aref, Jürgen Seidel   +2 more
doaj   +1 more source

Consistency of the full and reduced order models for evolve-filter-relax regularization of convection-dominated, marginally-resolved flows. [PDF]

Int J Numer Methods Eng, 2022
Strazzullo M, Girfoglio M, Ballarin F, Iliescu T, Rozza G.   +4 more
europepmc   +1 more source