Results 121 to 130 of about 19,863,493 (281)

Reduced joint models for damping design of multi-jointed structures [PDF]

, 2014
− Design of damping in multi-jointed structures is studied here. − Dissipation sources are viscoelastic behavior and contact/friction at joints interfaces. − Reduction on meta-models of nonlinear joints models is investigated.
BALMES, Etienne, GUSKOV, Mikhail, HAMMAMI, Chaima   +2 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Accelerated construction of projection-based reduced-order models via incremental approaches

Advanced Modeling and Simulation in Engineering Sciences
We present an accelerated greedy strategy for training of projection-based reduced-order models for parametric steady and unsteady partial differential equations.
Eki Agouzal, Tommaso Taddei
doaj   +1 more source

Design of Input Signal for System Identification of a Generic Fighter Configuration

Aerospace
This article investigates the design of time-accurate input signals in the angle-of-attack and pitch rate space to identify the aerodynamic characteristics of a generic triple-delta wing configuration at subsonic speeds.
Mehdi Ghoreyshi, Pooneh Aref, Jürgen Seidel   +2 more
doaj   +1 more source

Consistency of the full and reduced order models for evolve-filter-relax regularization of convection-dominated, marginally-resolved flows. [PDF]

Int J Numer Methods Eng, 2022
Strazzullo M, Girfoglio M, Ballarin F, Iliescu T, Rozza G.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Development of mechanistic reduced order models (ROMs)for glidant and lubricant effects in continuous manufacturing of pharmaceutical solid-dosage forms. [PDF]

ESCAPE, 2022
Bachawala S, Gonzalez M.
europepmc   +1 more source

Koopman Reduced-Order Modeling with Confidence Bounds

SIAM Journal on Applied Dynamical Systems
Abstract. This paper introduces a reduced-order modeling technique based on Koopman operator theory that gives confidence bounds on the model’s predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced-order model is constructed using a finite number of Koopman eigenvalues and modes, while ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire   +2 more sources