Results 91 to 100 of about 253,120 (262)
The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation
Journal of Cardiovascular Development and Disease, 2017 The cyclic 3′,5′-adenosine monophosphate (cAMP) sensor enzyme, EPAC1, is a candidate drug target in vascular endothelial cells (VECs) due to its ability to attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases ...
Graeme Barker +5 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
RGS proteins and G protein signalling [PDF]
The work within this thesis is concerned with the creation of a temperature-sensitive Schizosaccharomyces pombe marker protein, and the regulation of the pheromone communication system of Sz. pombe reporter strains by RGS proteins.
Pateman, Cassandra Sophie Catherine
core
Protein recruitment to receptor tyrosine kinase-mediated early signalling complexes. [PDF]
, 2007 Receptor tyrosine kinase (RTK) signalling regulates the activation of numerous cellular processes in response to various external stimuli. Spatio-temporal regulation of protein recruitment to activated tyrosine kinase receptors is important for the ...
Schller, A.C.
core
NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia [PDF]
, 2018 The movement of microglia is regulated mainly by P1 and P2 purinergic receptors, which are activated by various nucleotides and their metabolites.
이민구, 김주영
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FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy
FEBS Open Bio, 2015 Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function.
Jen Y. Lee +3 more
doaj +1 more source
PLoS ONE, 2013 Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying
Antonio J Ruiz-Alcaraz +6 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Gibberellin signalling - new opportunities for crop management [PDF]
, 2010 The potential for exploitation of the gibberellin (GA) plant growth hormones in agriculture was a major factor driving research on the physiological function of these substances following their introduction to the West from Japan in the 1950s.
Hedden, P. +5 more
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Molecular OncologyBone morphogenetic protein (BMP) antagonists have been increasingly linked to the development of colorectal cancer (CRC). BMP signalling operates in opposition to the WNT signalling pathway, which sustains stem‐cell maintenance and self‐renewal of the ...
Eloise Clarkson, Annabelle Lewis
doaj +1 more source