Results 81 to 90 of about 253,120 (262)

FGF and TGFbeta signalling in an in-vitro model of craniosynostosis [PDF]

, 2009
Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core  

CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia [PDF]

, 2013
The role of the microenvironment in the development and progression of chronic lymphocytic leukaemia (CLL) is currently of major interest. Pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) represent exogenous and ...
Vispute, K.
core   +1 more source

NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

PLoS ONE, 2022
Acute myeloid leukemia (AML) stem cells are required for the initiation and maintenance of the disease. Activation of the Wnt/β-catenin pathway is required for the survival and development of AML leukaemia stem cells (LSCs) and therefore, targeting β ...
Akbar Muhammed Shahid, In Hwa Um, Mustafa Elshani, Ying Zhang, David James Harrison   +4 more
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Understanding the role of gibberellin signalling in wheat anther development during heat stress [PDF]

, 2016
High temperature (HT) stress during wheat male reproductive development causes irreversible damage to the anther tapetum layer and the developing microspores it supports, resulting in reduced yield.
Audley, M.
core  

Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD [PDF]

, 2016
Iron is an indispensable micronutrient that regulates many aspects of cell function, including growth and proliferation. These processes are critically dependent upon signalling via the mammalian or mechanistic target of rapamycin complex 1 (mTORC1 ...
Watson, Ailsa, Taylor, Peter M., Hundal, Harinder, Lipina, Christopher, McArdle, Harry J., Hundal, Harinder S.   +5 more
core   +1 more source

Reduced expression of the serotonin transporter impacts mitochondria in a sexually dimorphic manner

Biochemistry and Biophysics Reports
Neuropsychiatric and neurodevelopmental disorders are complex conditions that arise from a variety of interacting genetic and environmental factors.
Bryony N. Thorne, Bart A. Ellenbroek, Darren J. Day   +2 more
doaj   +1 more source

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

Mediators of Inflammation, 2018
Several studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models.
Serena Tedesco, Morena Zusso, Laura Facci, Annalisa Trenti, Carlotta Boscaro, Federica Belluti, Gian Paolo Fadini, Stephen D. Skaper, Pietro Giusti, Chiara Bolego, Andrea Cignarella   +10 more
doaj   +1 more source