Results 101 to 110 of about 253,120 (262)

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

BMC Cancer, 2019
Background Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease.
Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux, George S. Baillie   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer

Cell Death and Disease
Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumour growth via
Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand   +14 more
doaj   +1 more source

Epidermal LysM receptor ensures robust symbiotic signalling in Lotus japonicus

eLife, 2018
Recognition of Nod factors by LysM receptors is crucial for nitrogen-fixing symbiosis in most legumes. The large families of LysM receptors in legumes suggest concerted functions, yet only NFR1 and NFR5 and their closest homologs are known to be required.
Eiichi Murakami, Jeryl Cheng, Kira Gysel, Zoltan Bozsoki, Yasuyuki Kawaharada, Christian Toftegaard Hjuler, Kasper Kildegaard Sørensen, Ke Tao, Simon Kelly, Francesco Venice, Andrea Genre, Mikkel Boas Thygesen, Noor de Jong, Maria Vinther, Dorthe Bødker Jensen, Knud Jørgen Jensen, Michael Blaise, Lene Heegaard Madsen, Kasper Røjkjær Andersen, Jens Stougaard, Simona Radutoiu   +20 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Reduced TCR-signalling contributes to impaired Th17 responses in tolerant kidney transplant recipients. [PDF]

, 2017
BACKGROUND: The development of spontaneous kidney transplant tolerance has been associated with numerous B cell-related immune alterations. We have previously shown that tolerant recipients exhibit reduced B cell receptor (BCR) signalling and higher IL ...
Marco Romano, Norris, Sonia, McGregor, R, Maria P. Hernandez-Fuentes, Mobillo, P, Sonia Norris, Nova-Lamperti, E, Paula Mobillo, Giovanna Lombardi, Romano, Marco, Christakoudi, Sofia, Tjir-Li Tsui, Christakoudi, S, Kamra, Y, Reuben McGregor, Nova-Lamperti, Estefania, Lechler, Robert I, Kamra, Yogesh, Lombardi, Giovanna, Lechler, RI, Runglall, Manohursingh, Boardman, Dominic A, Tsui, Tjir-Li, John, Susan; id_orcid, McGregor, Reuben, Mobillo, Paula, Boardman, DA, www.GAMBITstudy.co.uk, Hernandez-Fuentes, MP, Lombardi, G, Sofia Christakoudi, Dominic A. Boardman, Tsui, T-L, Robert I. Lechler, ?, ?, Norris, S, Runglall, M, John, S, Susan John, Hernandez-Fuentes, Maria P, Romano, M, Manohursingh Runglall, Estefania Nova-Lamperti, Yogesh Kamra   +43 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling [PDF]

, 2016
Hypoxic-ischaemic (HI) injury is an important cause of neurological morbidity in neonates. HI leads to pathophysiological responses, including inflammation and oxidative stress that culminate in cell death.
Sun, Yanyan,, Zhu, Changlian,, Sandberg, Mats,, D'angelo, Barbara,, Ek, C. Joakim,, Mallard, Carina,   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
Odile Mercereau-Puijalon, B. Naissant, F. Breil, Vernick Kenneth, Corbett Yolanda, Vernick, Kenneth D, Lavazec Catherine, Naissant Bernina, Duffier, Yoann, Naissant, Bernina, Eloise Thompson, Audrey Lorthiois (545164), Baker, David, A, Corbett, Yolanda, Duffier Yoann, Yolanda Corbett, Ghania Ramdani (676819), Vernick, Kenneth, Mercereau-Puijalon, Odile, Ramdani, Ghania, Yoann Duffier, Langsley Gordon, Ghania Ramdani, E. Thompson, Y. Corbett, K. Vernick, Audrey Lorthiois, Catherine Lavazec (106835), Dupuy, Florian, Gordon Langsley (85708), Gordon Langsley, Taramelli, Donatella, Baker, David ,, Florian Dupuy (616138), Lorthiois, Audrey, Bernina Naissant, Lavazec, Catherine, Dupuy Florian, Baker, David A, Catherine Lavazec, Odile Mercereau-Puijalon (58234), Mercereau-Puijalon Odile, David A Baker, Cummings Ross, Ross Cummings (736307), O. Mercereau Puijalon, Cummings, Ross, D. A. Baker, F. Dupuy, Florence Breil, Lorthiois Audrey, G. Langsley, Thompson Eloise, Y. Duffier, Florian Dupuy, Kenneth Vernick (736310), David A. Baker (122252), Baker, David,, A. Lorthiois, Breil Florence, Bernina Naissant (268019), R. Cummings, G. Ramdani, Yoann Duffier (736308), Donatella Taramelli, Ross Cummings, D. Taramelli, Ramdani Ghania, Taramelli Donatella, Langsley, Gordon, Baker David A., Kenneth Vernick, Thompson, Eloise, Florence Breil (736306), C. Lavazec, Eloise Thompson (376344), Yolanda Corbett (736309), Breil, Florence, Donatella Taramelli (736311)   +78 more
core   +1 more source