Results 31 to 40 of about 253,120 (262)

Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction. [PDF]

, 2016
Reduced mechanistic target of rapamycin (mTOR) signalling extends lifespan in yeast, nematodes, fruit flies and mice, highlighting a physiological pathway that could modulate aging in evolutionarily divergent organisms.
Nakagawa, S., Simons, M.J., Simons, Mirre J. P., Garratt, Michael, Garratt, M., Nakagawa, Shinichi   +5 more
core   +1 more source

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells.

PLoS Genetics, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C Norman, Margaret Frame, Marcos Vidal   +8 more
doaj   +1 more source

CaMKIIδ interacts directly with IKKβ and modulates NF-κB signalling in adult cardiac fibroblasts [PDF]

, 2018
Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease.
Beattie, J, Cunningham, Margaret R., Martin, TP, Currie, S, McCluskey, C, Cunningham, MR, Paul, Andrew, Martin, Tamara P., Currie, Susan, Beattie, James, Paul, A, McCluskey, Claire   +11 more
core   +1 more source

Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model. [PDF]

PLoS Genetics, 2019
Dipteran insects transmit serious diseases to humans, often in the form of trypanosomatid parasites. To accelerate research in more difficult contexts of dipteran-parasite relationships, we studied the interaction of the model dipteran Drosophila ...
Lihui Wang, Megan A Sloan, Petros Ligoxygakis   +2 more
doaj   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis

Nature Communications, 2017
CD103+ dendritic cells induce iTreg cells to maintain immune balance in the gut, but how CD40-signalling regulates this process is unclear. Here the authors show that mice with constitutive CD11c-specific CD40-signalling have altered CD103+dendritic cell
Christian Barthels, Ana Ogrinc, Verena Steyer, Stefanie Meier, Ferdinand Simon, Maria Wimmer, Andreas Blutke, Tobias Straub, Ursula Zimber-Strobl, Esther Lutgens, Peggy Marconi, Caspar Ohnmacht, Debora Garzetti, Bärbel Stecher, Thomas Brocker   +14 more
doaj   +1 more source

Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes

Scientific Reports, 2021
Estrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs following estrogen withdrawal (EW) and is associated with impaired focal ...
Ivor P. Geoghegan, Laoise M. McNamara, David A. Hoey   +2 more
doaj   +1 more source

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs [PDF]

, 2008
The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan. The seven insulin-like peptides (DILPs) in Drosophila are expressed in a stage- and tissue-specific manner.
Driege, Y., Driege Yasmine, Broughton, S, Broughton, Susan, Tommasi, AM, Partridge Linda, Hafen, Ernst, Cathy Slack, Tommasi Anna Maria, Anna Maria Tommasi, Slack, C, Broughton, S., Hafen, E., Nazif Alic, Broughton Susan, Alic, N, Partridge, Linda, Vinti Giovanna, Ikeya, T., Driege, Y, Giovanna Vinti, Ikeya Tomoatsu, Tomoatsu Ikeya, Alic, N., Bass, Timothy, Bass, T., Slack Cathy, Vinti, Giovanna, Linda Partridge, Herman, Christophe, Partridge, L., Timothy Bass, Ikeya, T, Tommasi, Anna Maria, Bass Timothy, Hafen Ernst, Alic Nazif, Hafen, E, Susan Broughton, Driege, Yasmine, Ernst Hafen, Slack, Cathy, Bass, T, Alic, Nazif, Ikeya, Tomoatsu, Partridge, L, Vinti, G, Tommasi, A.M., Slack, C., Yasmine Driege, Vinti, G.   +50 more
core   +1 more source

Reduced auxin signalling through the cyclophilin DIAGEOTROPICA impacts tomato fruit development and metabolism during ripening [PDF]

, 2022
Auxin is an important hormone playing crucial roles during fruit growth and ripening, however, the metabolic impact of changes in auxin signalling during tomato (Solanum lycopersicum L.) ripening remains unclear. Here, we investigated the significance of
Fernie, A., Peres, L., Araújo, W., de Oliveira, Medeiros, D., Rodrigues-Salvador, A., Nunes-Nesi, A., Carvalho, A., Siqueira, J., Omena-Garcia, R., Batista-Silva, W., Ribeiro, D., Zsögön, A., Oliveira Martins, A.   +13 more
core   +1 more source

Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity [PDF]

, 2009
Introduction: Factor X (FX) is a serine-protease playing a crucial role in the blood coagulation pathway and triggering intracellular signalling in a variety of cells via protease-activated receptors (PARs). By exploiting naturally occurring variants (
Reitsma PH, MONTI, Monia, MARCHETTI, Giovanna, BERNARDI, Francesco, BorensztajnKeren S, CANELLA, Alessandro, PINOTTI, Mirko, BRANCHINI, Alessio, Spek CA   +8 more
core   +3 more sources