Results 21 to 30 of about 253,120 (262)

Identification of polo‐like kinase 1 as a therapeutic target in murine lupus

Clinical & Translational Immunology, 2022
Introduction The signalling cascades that contribute to lupus pathogenesis are incompletely understood. We address this by using an unbiased activity‐based kinome screen of murine lupus.
Yaxi Li, Hongting Wang, Zijing Zhang, Chenling Tang, Xinjin Zhou, Chandra Mohan, Tianfu Wu   +6 more
doaj   +1 more source

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Nature Communications, 2017
Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smooth ...
Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell   +14 more
doaj   +1 more source

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappa B signalling in rat skeletal muscle cells by AMP-activated protein kinase [PDF]

, 2011
Sustained over-supply of saturated non-esterified 'free' fatty acids has been shown to promote skeletal muscle insulin resistance, which may be driven, in part, by an increase in inflammatory signalling within this tissue.
Charlotte J. Green, Kei Sakamoto, Hundal, Harinder S, Fogarty, Sarah, Hundal, Harinder S., Sakamoto, Kei, Katherine Macrae, Macrae, Katherine, Harinder S. Hundal, Green, Charlotte J., Green, Charlotte J, Hardie, D. Grahame, Sarah Fogarty, D. Grahame Hardie   +13 more
core   +1 more source

The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.

PLoS Genetics, 2019
SLC18B1 is a sister gene to the vesicular monoamine and acetylcholine transporters, and the only known polyamine transporter, with unknown physiological role.
Robert Fredriksson, Smitha Sreedharan, Karin Nordenankar, Johan Alsiö, Frida A Lindberg, Ashley Hutchinson, Anders Eriksson, Sahar Roshanbin, Diana M Ciuculete, Anica Klockars, Aniruddha Todkar, Maria G Hägglund, Sofie V Hellsten, Viktoria Hindlycke, Åke Västermark, Ganna Shevchenko, Gaia Olivo, Cheng K, Klas Kullander, Ali Moazzami, Jonas Bergquist, Pawel K Olszewski, Helgi B Schiöth   +22 more
doaj   +1 more source

Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway [PDF]

, 2003
The mechanism of adrenergically activated calcium signalling in isolated murine brown preadipocytes (stromal-vascular fraction) was studied with Fura-2.
Dolgacheva, LP, Bronnikov, GE, Abzhalelov, BB, Zhang, S-J, Zinchenko, VP   +4 more
core   +1 more source

The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signalling in mouse skeletal muscle [PDF]

, 2014
The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and cell ...
Adel F M Ibrahim, Yun-Bo Shi, Mitchell, Fiona E., Grant English (527945), Peter M Taylor, Taylor Peter M., Poncet, Nadège, Fiona E Mitchell, Ibrahim Adel F. M., English, Grant, J. Simon C Arthur (527946), Nadège Poncet, Victoria A McGuire, Yun-Bo Shi (193634), Arthur J. Simon C, McGuire Victoria A., Adel F. M. Ibrahim (188343), Grant English, Taylor, Peter M., Ibrahim, Adel F. M., Poncet Nadège, Nadège Poncet (527942), Victoria A. McGuire (527944), Peter M. Taylor (527947), McGuire, Victoria A., English Grant, Arthur, J. Simon C; id_orcid, Mitchell Fiona E., Shi Yun-Bo, Fiona E. Mitchell (527943), Shi, Yun-Bo, J Simon C Arthur   +31 more
core   +1 more source

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.

PLoS Biology, 2014
Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life of older people. Strikingly similar declines in sleep quality are seen during ageing in laboratory animals, including the fruit fly Drosophila.
Athanasios Metaxakis, Luke S Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, Linda Partridge   +6 more
doaj   +1 more source

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function [PDF]

, 2015
Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin.
Muhammad, K., Depner, H., Hell, S.W., Holt, Matthew, Lützkendorf, J., Loll, Bernhard, Walter, Alexander, Holt, M., Sigrist, S., Hollmann, C., Goettfert, F., Wahl, M.C., Bergeron, D.D., Goettfert, Fabian, Driller, J., Sigrist, Stephan J., Schmoranzer, J., Hell, S. ; https://orcid.org/, Muhammad, Karzan, Wahl, M., Rey, U., Goetz, Torsten, Depner, Harald, Bergeron, D., Böhme, M., Rey, Ulises, Reddy-Alla, Suneel, Holt, Mathew, Böhme, Mathias A., Driller, Jan H., Bergeron, Dominique D., Schreiner, Dietmar, Scheiffele, Peter, Walter, Alexander Matthias, Hollmann, Christina, Sigrist, S.J., Bergeron, Dominique Dufour, Walter, A., Böhme, M.A., Schmoranzer, Jan, Götz, T., Scheiffele, P., Driller, J.H., Matkovic, Tanja, Schreiner, D., Matkovic, T., Ramesh, Niraja, Lützkendorf, Janine, Hell, Stefan, Götz, Torsten, Luetzkendorf, Janine, Ramesh, N., Hell, Stefan W., Reddy-Alla, S., Walter, Alexander M., Wahl, Markus C., Göttfert, F., Reddy Alla, S., Walter, A.M., Loll, B.   +59 more
core   +1 more source

Signalling through the Type 1 Insulin-Like Growth Factor Receptor (IGF1R) Interacts with Canonical Wnt Signalling to Promote Neural Proliferation in Developing Brain

ASN Neuro, 2012
Signalling through the IGF1R [type 1 IGF (insulin-like growth factor) receptor] and canonical Wnt signalling are two signalling pathways that play critical roles in regulating neural cell generation and growth. To determine whether the signalling through
Qichen Hu, Seong Yong Lee, John R O'Kusky, Ping Ye   +3 more
doaj   +1 more source

Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Critical illness myopathy (CIM) is a debilitating condition characterized by the preferential loss of the motor protein myosin. CIM is a by‐product of critical care, attributed to impaired recovery, long‐term complications, and mortality.
Alex B. Addinsall, Nicola Cacciani, Anders Backéus, Yvette Hedström, Ganna Shevchenko, Jonas Bergquist, Lars Larsson   +6 more
doaj   +1 more source