Results 1 to 10 of about 232,340 (120)

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

eLife, 2021
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge   +15 more
doaj   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. [PDF]

PLoS ONE, 2014
Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt SFA-induced ...
Francesca Nardi, Christopher Lipina, David Magill, Rima Hage Hassan, Eric Hajduch, Alexander Gray, Harinder S Hundal   +6 more
doaj   +1 more source

Analysis of the roles of the Notch1 signalling pathway in modulating deoxynivalenol cytotoxicity

Ecotoxicology and Environmental Safety, 2022
Deoxynivalenol (DON) is a trichothecenes produced by fungi that is widespread and poses a threat to human and animal health. The Notch1 signalling pathway is tightly involved in cell fate determination.
Yeyi Xiao, Jie Wang, Jingneng Wang, Haifei Wang, Shenglong Wu, Wenbin Bao   +5 more
doaj   +1 more source

Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice [PDF]

Open Biology, 2016
Postnatal skeletal muscle growth results from the activation of satellite cells and/or an increase in protein synthesis. The Notch signalling pathway maintains satellite cells in a quiescent state, and once activated, sustains their proliferation and ...
Bilal Al Jaam, Katy Heu, Florian Pennarubia, Alexandre Segelle, Laetitia Magnol, Agnès Germot, Sébastien Legardinier, Véronique Blanquet, Abderrahman Maftah   +8 more
doaj   +1 more source

Optimal Rate Allocation in Cluster-Tree WSNs

Sensors, 2011
In this paper, we propose a solution to the problem of guaranteed time slot allocation in cluster-tree WSNs. Our design uses the so-called Network Utility Maximization (NUM) approach as far as we aim to provide a fair distribution of the available ...
Jose Lopez Vicario, Gonzalo Seco-Granados, Ignasi Vilajosana, Xavier Vilajosana, Antoni Morell   +4 more
doaj   +1 more source

Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing

Journal of Biomedical Science, 2023
The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matrix and cell signalling proteins. Cell signalling activates distinctive subsections of target genes, and different signalling pathways
Sandy Winfield Jere, Heidi Abrahamse, Nicolette Nadene Houreld   +2 more
doaj   +1 more source

Arabidopsis Target of Rapamycin Coordinates With Transcriptional and Epigenetic Machinery to Regulate Thermotolerance

Frontiers in Plant Science, 2021
Global warming exhibits profound effects on plant fitness and productivity. To withstand stress, plants sacrifice their growth and activate protective stress responses for ensuring survival.
Mohan Sharma, Muhammed Jamsheer K., Brihaspati Narayan Shukla, Manvi Sharma, Prakhar Awasthi, Sanjeet Kumar Mahtha, Gitanjali Yadav, Ashverya Laxmi   +7 more
doaj   +1 more source

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Communications Biology, 2022
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signalling in
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow   +21 more
doaj   +1 more source

Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

BMC Pulmonary Medicine, 2019
Background Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure.
Ming-wei Liu, Mei-xian Su, Deng-yun Tang, Li Hao, Xiang-Han Xun, Yun-qiao Huang   +5 more
doaj   +1 more source

Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's disease.

PLoS ONE, 2021
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced ...
John M Haynes, Shanti M Sibuea, Alita A Aguiar, Fangwei Li, Joan K Ho, Colin W Pouton   +5 more
doaj   +1 more source