Results 11 to 20 of about 253,120 (262)

Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction [PDF]

Biology Open, 2019
Development of the vertebrate central nervous system involves the co-ordinated differentiation of progenitor cells and the establishment of functional neural networks.
Iwan Jones, Anna-Carin Hägglund, Leif Carlsson   +2 more
doaj   +2 more sources

Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion [PDF]

Journal of Ovarian Research, 2010
Background Activation of bone morphogenetic protein (BMP)4 signalling in human ovarian cancer cells induces a number of phenotypic changes in vitro, including altered cell morphology, adhesion, motility and invasion, relative to normal human ovarian ...
Shepherd Trevor G, Mujoomdar Michelle L, Nachtigal Mark W   +2 more
doaj   +3 more sources

The reduced kinome of Ostreococcus tauri: core eukaryotic signalling components in a tractable model species [PDF]

, 2014
## Background ## The current knowledge of eukaryote signalling originates from phenotypically diverse organisms. There is a pressing need to identify conserved signalling components among eukaryotes, which will lead to the transfer of knowledge ...
Barrios-Llerena, Martin E, Simpson, T Ian, Martin, Sarah F, Le Bihan, Thierry, Millar, Andrew J, Hindle, Matthew M, van Ooijen, Gerben, Noordally, Zeenat B   +7 more
core   +6 more sources

JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes [PDF]

, 2020
BACKGROUND: Salt-inducible kinase 2 (SIK2) is abundant in adipocytes, but downregulated in adipose tissue from individuals with obesity and insulin resistance.
Vavakova, M, Negoita, F, Saell, J, Negoita, Florentina, Göransson, Olga, Laurencikiene, J,, Vavakova, Magdalena, Säll, Johanna, Goeransson, O, Laurencikiene, Jurga   +9 more
core   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy

Journal of Diabetes Research, 2017
Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational maternal obesity (PGMO).
Roberto Villalobos-Labra, Luis Silva, Mario Subiabre, Joaquín Araos, Rocío Salsoso, Bárbara Fuenzalida, Tamara Sáez, Fernando Toledo, Marcelo González, Claudia Quezada, Fabián Pardo, Delia I. Chiarello, Andrea Leiva, Luis Sobrevia   +13 more
doaj   +1 more source

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling [PDF]

European Cells & Materials, 2017
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte ...
CL Thompson, JCT Plant, AKT Wann, CL Bishop, P Novak, HM Mitchison, PL Beales, JP Chapple, MM Knight   +8 more
doaj   +1 more source

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signalling [PDF]

, 2014
Dysfunctional regulation of signalling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes.
Kruse, Michael, Engelhardt, Stefan, Pfeiffer, Andreas F. H., Pan, Zhen-Qiang, Hartmann, Thomas, Scheufele, Florian, Mühlich, Susanne, Field, Loren J., Charron, Maureen J., Sarikas, Antonio, Wolf, Benjamin, Lempart, Justine   +11 more
core   +2 more sources

Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Nature Communications, 2016
Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to ...
Martin H. Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F. Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L. Michaud, Graziella Di Cristo   +14 more
doaj   +1 more source

The primary cilium influences interleukin-1 beta-induced NF kappa B signalling by regulating IKK activity [PDF]

, 2014
The primary cilium is an organelle acting as a master regulator of cellular signalling. We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and ...
Knight, M.M., Chapple, JP, Chapple, J.P., Wann, A.K.T., Knight, MM, Wann, AKT   +5 more
core   +1 more source