Results 141 to 150 of about 15,334 (300)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Q-reducibility and m-reducibility on computably enumerable sets [PDF]
, 2014 © 2014, Pleiades Publishing, Ltd. We study the distinctions between Q-reducibility and m-reducibility on computably enumerable sets. We construct a noncomputable m-incomplete computably enumerable set B such that all computably enumerable sets A ≤QB ...
Batyrshin I.
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A definition of self-reducibility is proposed to deal with logarithmic space complexity classes. A general property derived from the definition is used to prove known results comparing uniform and nonuniform complexity classes below polynomial time, and ...
Balcázar Navarro, José Luis
core
On the Extensions of Solovay-Reducibility
, 2008 . A c.e. real x is Solovay reducible (S-reducible) to another c.e. real y if y is at least as difficult to be approximated as x. In this case, y is at least as random as x. Thus, the S-reducibility classifies relative randomness of c.e.
Xizhong Zheng, Robert Rettinger
core
Limitwise monotonic reducibility on sets and on pairs of sets
, 2020 © 2016, Allerton Press, Inc.We study limitwise monotonic sets and pairs of sets. We investigate the properties of limitwise monotonic reducibility between sets and pairs of sets defined in terms of Σ-reducibility corresponding to initial segment of sets.
Zainetdinov D.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source