Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Effect of the Y<sub>2</sub>O<sub>3</sub> Promoter on the Structure of the Ni/Al<sub>2</sub>O<sub>3</sub> Catalyst for Ethanol Autothermal Reforming. [PDF]
Cambunda AP +4 more
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Role of Oxygen Vacancies in Fe/Ru-Based Catalysts for the Reverse Water Gas Shift Reaction: Performance and Characterization. [PDF]
Dole H +5 more
europepmc +1 more source
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Arthroscopic Medial Meniscus Posterior Root Repair and Centralization With Medial Capsulodesis Using a Knotless Soft Anchor. [PDF]
Radaelli S +5 more
europepmc +1 more source
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
CeO<sub>2</sub> Promoted CuO/MgO-Al<sub>2</sub>O<sub>3</sub> Catalyst with Enhanced Activity and Water-Resistance for CO Oxidation. [PDF]
Ye K +7 more
europepmc +1 more source
A Case Report on the Management of Peri-Prosthetic Fracture in a Post-TKA Patient with Rheumatoid Arthritis: Surgical Strategy and Treatment Outcome. [PDF]
Rosario PMM, Ra REV.
europepmc +1 more source

