Results 1 to 10 of about 670,508 (357)
Pteridines, 1993 Summary During the past decade numerous advances have been made in understanding the structure, mechanism and clinical properties of dihydropteridine reductase. An attempt is made here to delineate the current status of this essential enzyme by describing its structural features, its kinetic mechanism, the cloning and expression of both rat and human ...
Whiteley John M. +4 more
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Molecules, 2021 Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for ...
Dongjin Leng +7 more
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Molecules, 2023 The mitochondrial amidoxime-reducing component (mARC) is the most recently discovered molybdoenzyme in humans after sulfite oxidase, xanthine oxidase and aldehyde oxidase. Here, the timeline of mARC’s discovery is briefly described. The story begins with
Bernd Clement, Michel A. Struwe
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Biomolecules, 2023 A unique cytochrome P450 (CYP) oxidoreductase (CPR) sustains activities of human microsomal CYPs. Its function requires toggling between a closed conformation enabling electron transfers from NADPH to FAD and then FMN cofactors and open conformations ...
Francisco Esteves +8 more
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Phytophthora capsici sterol reductase PcDHCR7 has a role in mycelium development and pathogenicity
Open Biology, 2022 The de novo biosynthesis of sterols is critical for the majority of eukaryotes; however, some organisms lack this pathway, including most oomycetes. Phytophthora spp.
Weizhen Wang +6 more
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Chromium bioremediation by Alcaligenes sp. strain newly isolated from chromite mine of Sabzevar [PDF]
Journal of Advances in Environmental Health Research, 2017 In this work, CKCr-6A strain was found to be highly resistant to some toxic heavy metals such as Cr+6, Cr+3, Cu+2, Co+2, Cd+2, Pb+2, Hg+2, U+6, tellurium, and selenite. Herein, high chromate tolerance of an isolated strain is reported with a high minimum
Mohsen Mesbahi-Nowrouzi +2 more
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Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance
Antioxidants, 2022 Deinococcus species possess remarkable tolerance to extreme environmental conditions that generate oxidative damage to macromolecules. Among enzymes fulfilling key functions in metabolism regulation and stress responses, thiol reductases (TRs) harbour ...
Arjan de Groot +3 more
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Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase [PDF]
Journal of Biological Chemistry, 2008 Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics.
Brandon Tavshanjian +4 more
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Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle
Frontiers in Molecular Biosciences, 2023 Biliverdin Reductase B (BLVRB) is an NADPH-dependent reductase that catalyzes the reduction of multiple substrates and is therefore considered a critical cellular redox regulator.
Eunjeong Lee +6 more
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Ketopantoyl lactone reductase is a conjugated polyketone reductase [PDF]
FEMS Microbiology Letters, 1989 Ketopantoyl lactone reductase (EC 1.1.1.168) of Saccharomyces cerevisiae was found to catalyze the reduction of a variety of natural and unnatural conjugated polyketone compounds and quinones, such as isatin, ninhydrin, camphorquinone and beta-naphthoquinone in the presence of NADPH. 5-Bromoisatin is the best substrate for the enzyme (Km = 3.1 mM; Vmax
Sakayu Shimizu +3 more
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