Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]
, 1971 Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W. +50 more
core +1 more source
Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis [PDF]
, 2015 Aim: Molecular dynamics simulations and normal mode analysis are well-established approaches to generate receptor conformational ensembles (RCEs) for ligand docking and virtual screening.
David Perahia +10 more
core +4 more sources
Dyslipidemic drugs in metabolic syndrome
Indian Journal of Endocrinology and Metabolism, 2013 Introduction: Metabolic syndrome predisposes to diabetes and atherosclerotic vascular disease. Statins reduce cardiovascular events, so all metabolic syndrome patients should be evaluated for dyslipidemia.
Sheelu S Siddiqi +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The human six-transmembrane epithelial antigen of the prostate (STEAP) proteins, which include STEAP1–4 and atypical STEAP1B, contain six transmembrane domains and are located in the cell membrane.
Wen-Jia Chen +6 more
doaj +1 more source
Study of the Cys-His bridge electron transfer pathway in a copper-containing nitrite reductase by site-directed mutagenesis, spectroscopic, and computational methods [PDF]
, 2018 The Cys-His bridge as electron transfer conduit in the enzymatic catalysis of nitrite to nitric oxide by nitrite reductase from Sinorhizobium meliloti 2011 (SmNir) was evaluated by site-directed mutagenesis, steady state kinetic studies, UV-vis and EPR ...
Brondino, Carlos Dante +7 more
core +1 more source
Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
Frontiers in Molecular Biosciences, 2021 The biliverdin reductase B (BLVRB) class of enzymes catalyze the NADPH-dependent reduction of multiple flavin substrates and are emerging as critical players in cellular redox regulation.
Jasmina S. Redzic +5 more
doaj +1 more source
Aldose Reductase Inhibitors [PDF]
Journal of Enzyme Inhibition, 2001 Aldose reductase ([EC1.1.1.21]: AR) acts on the first step of the polyol metabolic pathway to catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the pathway in individuals with high blood glucose level is closely related to the onset or progression of diabetic complications.
M, Oka, N, Kato
openaire +2 more sources
Highly diverse nirK genes comprise two major clades that harbour ammonium-producing denitrifiers [PDF]
, 2016 Background: Copper dependent nitrite reductase, NirK, catalyses the key step in denitrification, i.e. nitrite reduction to nitric oxide. Distinct structural NirK classes and phylogenetic clades of NirK-type denitrifiers have previously been observed ...
Decleyre, Helen +3 more
core +3 more sources
Two DsbA Proteins Are Important for Vibrio parahaemolyticus Pathogenesis
Frontiers in Microbiology, 2019 Bacterial pathogens maintain disulfide bonds for protein stability and functions that are required for pathogenesis. Vibrio parahaemolyticus is a Gram-negative pathogen that causes food-borne gastroenteritis and is also an important opportunistic ...
Chun-qin Wu +8 more
doaj +1 more source
Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly
Molecules, 2022 The Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the ...
Markus W. Ribbe +7 more
doaj +1 more source