Results 41 to 50 of about 336,111 (290)

Imine reductases (IREDs)

Current Opinion in Chemical Biology, 2017
Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes.
Mangas-Sanchez, Juan, France, Scott P, Montgomery, Sarah L, Aleku, Godwin A, Man, Henry, Sharma, Mahima, Ramsden, Jeremy I, Grogan, Gideon, Turner, Nicholas J   +8 more
openaire   +4 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

NITRATE REDUCTASE ACTIVITY OF SULPHATE-REDUCING BACTERIA Desulfomicrobium SP. CrR3 AT THE DIFFERENT CONDITIONS OF THE CULTIVATION [PDF]

Biotechnologia Acta, 2016
The aim of research was to study nitrate reductase activity of sulphate-reducing bacteria Desulfomicrobium sp. CrR3 at the different conditions of cultivation. To determine nitrate reductase activity, sulphate-reducing bacteria Desulfomicrobium sp.
L. S. , T. B. , S. P.
doaj   +1 more source

Catalysis in fumarate reductase

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2000
In the absence of oxygen many bacteria are able to utilise fumarate as a terminal oxidant for respiration. In most known organisms the fumarate reductases are membrane-bound iron-sulfur flavoproteins but Shewanella species produce a soluble, periplasmic flavocytochrome c(3) that catalyses this reaction.
Katherine L Pankhurst, Graeme A Reid, Caroline S Miles, R Moysey, Stephen K Chapman   +4 more
openaire   +3 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity[S]

Journal of Lipid Research, 2010
NCB5OR is a novel flavoheme reductase with a cytochrome b5-like domain at the N-terminus and a cytochrome b5 reductase-like domain at the C terminus. Ncb5or knock-out mice develop insulin deficient diabetes and loss of white adipose tissue.
Yongzhao Zhang, Kevin Larade, Zhi-gang Jiang, Susumu Ito, WenFang Wang, Hao Zhu, H. Franklin Bunn   +6 more
doaj  

Growth and Mineral Nutrition of the Chickpea ( Cicer arietinum L.)-Rhizobia Symbiosis under Water Deficit

Brazilian Archives of Biology and Technology, 2018
The effect of the water deficit on the fresh and dry weight in the various parts of the plant and on several mineral processes in different symbiotic combinations for the chickpea (Cicer arietinum L.) varieties was studied.
Ahmed Khadraji, Mohammed Mouradi, Cherki Ghoulam   +2 more
doaj   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Electrochemical Biosensing of Glucose Based on the Enzymatic Reduction of Glucose

Sensors, 2022
In this work, the enzyme aldehyde reductase, also known as aldose reductase, was synthesized and cloned from a human gene. Spectrophotometric measurements show that in presence of the nicotinamide adenine dinucleotide phosphate cofactor (NADPH), the ...
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda   +8 more
doaj   +1 more source

Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis

Arthritis Care &Research, EarlyView.
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp, Anne Horne, Borislav Mihov, Jill Drake, Janine Haslett, Peter Chapman, Daniel F. B. Wright, Christopher Frampton, Nicola Dalbeth   +8 more
wiley   +1 more source