Results 81 to 90 of about 854,050 (403)

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity

Journal of Lipid Research, 1980
We have investigated the comparative biochemistry of in vitro regulation of HMG-CoA reductase (EC 1.1.1.34) in microsomal preparations from the livers of nine vertebrates.
C F Hunter, V W Rodwell
doaj   +1 more source

A Case of Statin-Associated Autoimmune Myopathy. [PDF]

, 2017
A 70-year-old previously independent man developed progressive proximal leg weakness resulting in a fall at home suffering traumatic brain injury. He was prescribed a statin medication two years prior, but this was discontinued on admission to the ...
Dokukin, Andrei N, Farjami, Sassan, Kaiser, Cassandra J, Leung, Anthony, Romansky, Stephen, Strube, Sarah J, Sweidan, Alexander J   +6 more
core   +3 more sources

Quinone Reductase 2 Is a Catechol Quinone Reductase [PDF]

Journal of Biological Chemistry, 2008
The functions of quinone reductase 2 have eluded researchers for decades even though a genetic polymorphism is associated with various neurological disorders. Employing enzymatic studies using adrenochrome as a substrate, we show that quinone reductase 2 is specific for the reduction of adrenochrome, whereas quinone reductase 1 shows no activity.
Yue, Fu, Leonid, Buryanovskyy, Zhongtao, Zhang   +2 more
openaire   +2 more sources

Differential molecular response of monodehydroascorbate reductase and glutathione reductase by nitration and S-nitrosylation

Journal of Experimental Botany, 2015
Highlight Nitration and S-nitrosylation, two post-translational modifications (PTMs) mediated by nitric oxide, differentially regulate MDAR and GR activities which are key components of the ascorbate–glutathione cycle.
J. Begara-Morales, Beatriz Sánchez-Calvo, Mounira Chaki, Capilla Mata-Pérez, R. Valderrama, M. N. Padilla, J. López-Jaramillo, F. Luque, F. J. Corpas, J. B. Barroso   +9 more
semanticscholar   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Comparative studies on the soluble and plasma membrane associated nitrate reductase from Cucumis sativus L.

Acta Societatis Botanicorum Poloniae, 2014
The biochemical comparison between two forms of nitrate reductase from cucumber roots: the soluble enzyme and the plasma membrane-associated one was made. Soluble nitrate reductase was purified on the blue-Sepharose 4B.
Grażyna Kłobus, Jolanta Marciniak, Józef Buczek   +2 more
doaj   +1 more source

Microbial degradation of dimethylsulphide and related C1-sulphur compounds: organisms and pathways controlling fluxes of sulphur in the biosphere [PDF]

, 2010
Dimethylsulphide (DMS) plays a major role in the global sulphur cycle. It has important implications for atmospheric chemistry, climate regulation, and sulphur transport from the marine to the atmospheric and terrestrial environments.
Boden, Rich, Myronova, Natalia, Schäfer, Hendrik   +2 more
core   +1 more source

Dihydrodipicolinic Acid Reductase

Journal of Biological Chemistry, 1974
Abstract The enzyme dihydrodipicolinic acid reductase catalyzes a pyridine nucleotide-linked reduction of dihydrodipicolinic acid to tetrahydrodipicolinic acid in the biosynthetic pathway leading to diaminopimelic acid and lysine in bacteria. Modification of the procedure published previously and additional purification steps led to a preparation of ...
H, Tamir, C, Gilvarg
openaire   +2 more sources

Aldose and Aldehyde Reductase Exhibit Isocorticosteroid Reductase Activity [PDF]

European Journal of Biochemistry, 1983
In this paper we describe the reduction of corticosteroid metabolites containing the 17 beta-aldol side chain (isocorticosteroids) by aldose and aldehyde reductase from human tissues. Aldose reductase catalyzed the reduction of the aldehydes derived from cortisol and corticosterone at about the same rate, whereas aldehyde reductase preferentially acted
B, Wermuth, C, Monder
openaire   +2 more sources