Results 71 to 80 of about 623,822 (311)

キイロショウジョウバエ由来のチオレドキシン還元酵素のC未端テトラペプチド配列は、ヒト肺由来のチオレドキシン還元酵素では酸化還元活性を示さない [PDF]

, 2007
The isozymes of mammalian thioredoxin reductase (TrxR) contain the penultimate selenocysteineresidue (SeCys) in the redox-active C-terminal tetrapeptide, -Gly-Cys-SeCys-Gly (end). Amutant form of the mammalian enzyme TrxR-X498C in which SeCys is replaced
Inagaki, Kenji, Kawamura, Kentaro, Kuwahara, Mitsuhiko, Tamura, Takashi   +3 more
core  

The NADPH-Dependent thioredoxin reductase C-2-Cys peroxiredoxin redox system modulates the activity of thioredoxin x in arabidopsis chloroplasts [PDF]

, 2018
The chloroplast redox network is composed of a complex set of thioredoxins (Trxs), reduced by ferredoxin (Fdx) via a Fdx-dependent Trx reductase (FTR), and an NADPH-dependent Trx reductase with a joint Trx domain, NTRC, which efficiently reduces 2-Cys ...
Cejudo Fernández, Francisco Javier, Ojeda Servián, Valle, Pérez Ruiz, Juan Manuel   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genome-wide analysis of OPR family genes in Vitis vinifera and the role of VvOPR1 in copper, zinc tolerance

Frontiers in Plant Science
12-oxo-phytodienoic acid reductase (OPR) is one of the key enzymes in the octadecanoid pathway, and it controls the last step of jasmonic acid (JA) biosynthesis.
Shuang-Hong You, Yuan-Ping Chen, Wen-Jing Shi, Xue Li, Zheng Wu, Quan-Hong Yao   +5 more
doaj   +1 more source

NITRATE REDUCTASE ACTIVITY OF SULPHATE-REDUCING BACTERIA Desulfomicrobium SP. CrR3 AT THE DIFFERENT CONDITIONS OF THE CULTIVATION [PDF]

Biotechnologia Acta, 2016
The aim of research was to study nitrate reductase activity of sulphate-reducing bacteria Desulfomicrobium sp. CrR3 at the different conditions of cultivation. To determine nitrate reductase activity, sulphate-reducing bacteria Desulfomicrobium sp.
L. S. , T. B. , S. P.
doaj   +1 more source

Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization [PDF]

, 2011
Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown
Chan, Sunney I., Chen, Chun-Jung, Chiang, Yuan-Lan, Chuankhayan, Phimonphan, Fang, Jou-Yin, Hsieh, Yin-Cheng, Huang, Yen-Chieh, Liu, Ming-Yih, Wang, Vincent C.-C., Yang, Ming-Chi   +9 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Can Molybdenum Fertilization Enhance Protein Content and Digestibility of Sorghum Single Cropped and Intercropped with Cowpea?

Grasses
Molybdenum fertilization represents a viable alternative for improving forage quality, potentially complementing or enhancing the effects of nitrogen fertilization.
Nágila Sabrina Guedes da Silva, Alexandre Campelo de Oliveira, Baltazar Cirino Júnior, Rhaiana Oliveira de Aviz, Kedes Paulo Pereira, Domingos Sávio Marques de Menezes Vieira, Claudenilde de Jesus Pinheiro Costa, Jucelane Salvino de Lima, Jamiles Carvalho Gonçalves de Souza Henrique, Evaristo Jorge Oliveira de Souza   +9 more
doaj   +1 more source

Ketopantoyl lactone reductase is a conjugated polyketone reductase [PDF]

FEMS Microbiology Letters, 1989
Ketopantoyl lactone reductase (EC 1.1.1.168) of Saccharomyces cerevisiae was found to catalyze the reduction of a variety of natural and unnatural conjugated polyketone compounds and quinones, such as isatin, ninhydrin, camphorquinone and beta-naphthoquinone in the presence of NADPH. 5-Bromoisatin is the best substrate for the enzyme (Km = 3.1 mM; Vmax
H, Hata, S, Shimizu, S, Hattori, H, Yamada   +3 more
openaire   +2 more sources